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The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.
Madan E, Parker TM, Bauer MR, Dhiman A, Pelham CJ, Nagane M, Kuppusamy ML, Holmes M, Holmes TR, Shaik K, Shee K, Kiparoidze S, Smith SD, Park YA, Gomm JJ, Jones LJ, Tomás AR, Cunha AC, Selvendiran K, Hansen LA, Fersht AR, Hideg K, Gogna R, Kuppusamy P. Madan E, et al. Among authors: bauer mr. J Biol Chem. 2018 Mar 23;293(12):4262-4276. doi: 10.1074/jbc.RA117.000950. Epub 2018 Jan 30. J Biol Chem. 2018. PMID: 29382728 Free PMC article.
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.
Vogel SM, Bauer MR, Joerger AC, Wilcken R, Brandt T, Veprintsev DB, Rutherford TJ, Fersht AR, Boeckler FM. Vogel SM, et al. Among authors: bauer mr. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16906-10. doi: 10.1073/pnas.1215060109. Epub 2012 Oct 3. Proc Natl Acad Sci U S A. 2012. PMID: 23035244 Free PMC article.
SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.
Gomes S, Bosco B, Loureiro JB, Ramos H, Raimundo L, Soares J, Nazareth N, Barcherini V, Domingues L, Oliveira C, Bisio A, Piazza S, Bauer MR, Brás JP, Almeida MI, Gomes C, Reis F, Fersht AR, Inga A, Santos MMM, Saraiva L. Gomes S, et al. Among authors: bauer mr. Cancers (Basel). 2019 Aug 10;11(8):1151. doi: 10.3390/cancers11081151. Cancers (Basel). 2019. PMID: 31405179 Free PMC article.
98 results