Ajjala DR - Search Results

1

Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole.

Palacharla RC, Molgara P, Panthangi HR, Boggavarapu RK, Manoharan AK, Ponnamaneni RK, Ajjala DR, Nirogi R. Palacharla RC, et al. Among authors: ajjala dr. Xenobiotica. 2019 Feb;49(2):169-176. doi: 10.1080/00498254.2018.1434913. Epub 2018 Feb 15. Xenobiotica. 2019. PMID: 29382249

2

Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays.

Nirogi R, Palacharla RC, Uthukam V, Manoharan A, Srikakolapu SR, Kalaikadhiban I, Boggavarapu RK, Ponnamaneni RK, Ajjala DR, Bhyrapuneni G. Nirogi R, et al. Among authors: ajjala dr. Xenobiotica. 2015 Feb;45(2):95-106. doi: 10.3109/00498254.2014.945196. Epub 2014 Jul 29. Xenobiotica. 2015. PMID: 25070627

3

Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clearance.

Palacharla RC, Uthukam V, Manoharan A, Ponnamaneni RK, Padala NP, Boggavarapu RK, Bhyrapuneni G, Ajjala DR, Nirogi R. Palacharla RC, et al. Among authors: ajjala dr. Eur J Pharm Sci. 2017 Apr 1;101:80-89. doi: 10.1016/j.ejps.2017.01.027. Epub 2017 Feb 4. Eur J Pharm Sci. 2017. PMID: 28179134

4

Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes).

Palacharla VRC, Chunduru P, Ajjala DR, Bhyrapuneni G, Nirogi R, Li AP. Palacharla VRC, et al. Among authors: ajjala dr. Drug Metab Dispos. 2019 Oct;47(10):1032-1039. doi: 10.1124/dmd.119.088237. Epub 2019 Aug 2. Drug Metab Dispos. 2019. PMID: 31375472

5

Simultaneous in-vivo receptor occupancy assays for serotonin 1A, 2A, and dopamine 2 receptors with the use of non-radiolabelled tracers: Proposed method in screening antipsychotics.

Thentu JB, Nirogi R, Bhyrapuneni G, Ajjala DR, Aleti RR, Palacharla RC. Thentu JB, et al. Among authors: ajjala dr. J Pharmacol Toxicol Methods. 2017 May-Jun;85:22-28. doi: 10.1016/j.vascn.2017.01.001. Epub 2017 Jan 4. J Pharmacol Toxicol Methods. 2017. PMID: 28063918

6

Incurred sample reanalysis of fingolimod and fingolimod phosphate in blood: stability evaluation and application to a rat pharmacokinetic study.

Nirogi R, Padala NP, Ajjala DR, Boggavarapu RK, Kunduru P. Nirogi R, et al. Among authors: ajjala dr. Bioanalysis. 2017 Apr;9(7):565-577. doi: 10.4155/bio-2016-0308. Epub 2017 Mar 16. Bioanalysis. 2017. PMID: 28300418

7

LC-MS/MS method for quantification of 3,4-dihydroxyphenylglycol, a norepinephrine metabolite in plasma and brain regions.

Padala NSP, Ajjala DR, Boggavarapu RK, Pantangi HR, Thentu JB, Mohammed AR, Nirogi R. Padala NSP, et al. Among authors: ajjala dr. Bioanalysis. 2019 May;11(10):971-986. doi: 10.4155/bio-2019-0023. Bioanalysis. 2019. PMID: 31218903

8

Skin sample preparation by collagenase digestion for diclofenac quantification using LC-MS/MS after topical application.

Nirogi R, Padala NS, Boggavarapu RK, Kalaikadhiban I, Ajjala DR, Bhyrapuneni G, Muddana NR. Nirogi R, et al. Among authors: ajjala dr. Bioanalysis. 2016 Jun;8(12):1251-63. doi: 10.4155/bio-2016-0031. Epub 2016 May 26. Bioanalysis. 2016. PMID: 27226048

9

Development and validation of sensitive LC-MS/MS method for the quantification of SUVN-502 and its metabolite and its application for first in human pharmacokinetic study.

Nirogi R, Ajjala DR, Aleti R, Rayapati L, Pantangi HR, Boggavarapu RK, Padala NSP. Nirogi R, et al. Among authors: ajjala dr. J Pharm Biomed Anal. 2017 Oct 25;145:423-430. doi: 10.1016/j.jpba.2017.04.005. Epub 2017 Apr 14. J Pharm Biomed Anal. 2017. PMID: 28734271

10

Absorption, distribution, metabolism, excretion (ADME), drug-drug interaction potential and prediction of human pharmacokinetics of SUVN-G3031, a novel histamine 3 receptor (H₃R) inverse agonist in clinical development for the treatment of narcolepsy.

Nirogi R, Bhyrapuneni G, Muddana NR, Manoharan A, Shinde AK, Mohammed AR, Padala NP, Ajjala DR, Subramanian R, Palacharla VRC. Nirogi R, et al. Among authors: ajjala dr. Eur J Pharm Sci. 2020 Sep 1;152:105425. doi: 10.1016/j.ejps.2020.105425. Epub 2020 Jun 10. Eur J Pharm Sci. 2020. PMID: 32534194

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