Lakshminarayanan R - Search Results

1

Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo.

Parmar A, Lakshminarayanan R, Iyer A, Mayandi V, Leng Goh ET, Lloyd DG, Chalasani MLS, Verma NK, Prior SH, Beuerman RW, Madder A, Taylor EJ, Singh I. Parmar A, et al. Among authors: lakshminarayanan r. J Med Chem. 2018 Mar 8;61(5):2009-2017. doi: 10.1021/acs.jmedchem.7b01634. Epub 2018 Feb 15. J Med Chem. 2018. PMID: 29363971

2

The structural parameters for antimicrobial activity, human epithelial cell cytotoxicity and killing mechanism of synthetic monomer and dimer analogues derived from hBD3 C-terminal region.

Zhou L, Liu SP, Chen LY, Li J, Ong LB, Guo L, Wohland T, Tang CC, Lakshminarayanan R, Mavinahalli J, Verma C, Beuerman RW. Zhou L, et al. Among authors: lakshminarayanan r. Amino Acids. 2011 Jan;40(1):123-33. doi: 10.1007/s00726-010-0565-8. Epub 2010 Apr 17. Amino Acids. 2011. PMID: 20397033

3

Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities.

Liu SP, Zhou L, Lakshminarayanan R, Beuerman RW. Liu SP, et al. Among authors: lakshminarayanan r. Int J Pept Res Ther. 2010 Sep;16(3):199-213. doi: 10.1007/s10989-010-9230-z. Epub 2010 Aug 26. Int J Pept Res Ther. 2010. PMID: 20835389 Free PMC article.

4

A novel mutation in transforming growth factor-beta induced protein (TGFβIp) reveals secondary structure perturbation in lattice corneal dystrophy.

Lakshminarayanan R, Vithana EN, Chai SM, Chaurasia SS, Saraswathi P, Venkatraman A, Rojare C, Venkataraman D, Tan D, Aung T, Beuerman RW, Mehta JS. Lakshminarayanan R, et al. Br J Ophthalmol. 2011 Oct;95(10):1457-62. doi: 10.1136/bjophthalmol-2011-300651. Epub 2011 Aug 10. Br J Ophthalmol. 2011. PMID: 21835759

5

Expression, purification and characterization of fourth FAS1 domain of TGFβIp-associated corneal dystrophic mutants.

Elavazhagan M, Lakshminarayanan R, Zhou L, Ting LW, Tong L, Beuerman RW, Chaurasia SS, Mehta JS. Elavazhagan M, et al. Among authors: lakshminarayanan r. Protein Expr Purif. 2012 Jul;84(1):108-15. doi: 10.1016/j.pep.2012.04.018. Epub 2012 May 2. Protein Expr Purif. 2012. PMID: 22575305

6

Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target.

Bai Y, Liu S, Li J, Lakshminarayanan R, Sarawathi P, Tang C, Ho D, Verma C, Beuerman RW, Pervushin K. Bai Y, et al. Among authors: lakshminarayanan r. J Biol Chem. 2012 Aug 3;287(32):26606-17. doi: 10.1074/jbc.M112.363259. Epub 2012 Jun 14. J Biol Chem. 2012. PMID: 22700968 Free PMC article.

7

Dual functionalization of titanium with vascular endothelial growth factor and β-defensin analog for potential application in keratoprosthesis.

Tan XW, Lakshminarayanan R, Liu SP, Goh E, Tan D, Beuerman RW, Mehta JS. Tan XW, et al. Among authors: lakshminarayanan r. J Biomed Mater Res B Appl Biomater. 2012 Nov;100(8):2090-100. doi: 10.1002/jbm.b.32774. Epub 2012 Jul 23. J Biomed Mater Res B Appl Biomater. 2012. PMID: 22821845 Clinical Trial.

8

Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting.

Koh JJ, Qiu S, Zou H, Lakshminarayanan R, Li J, Zhou X, Tang C, Saraswathi P, Verma C, Tan DT, Tan AL, Liu S, Beuerman RW. Koh JJ, et al. Among authors: lakshminarayanan r. Biochim Biophys Acta. 2013 Feb;1828(2):834-44. doi: 10.1016/j.bbamem.2012.09.004. Epub 2012 Sep 13. Biochim Biophys Acta. 2013. PMID: 22982495 Free article.

9

Molecular dynamics simulations of a new branched antimicrobial peptide: a comparison of force fields.

Li J, Lakshminarayanan R, Bai Y, Liu S, Zhou L, Pervushin K, Verma C, Beuerman RW. Li J, et al. Among authors: lakshminarayanan r. J Chem Phys. 2012 Dec 7;137(21):215101. doi: 10.1063/1.4768899. J Chem Phys. 2012. PMID: 23231260

10

Molecular simulations suggest how a branched antimicrobial peptide perturbs a bacterial membrane and enhances permeability.

Li J, Liu S, Lakshminarayanan R, Bai Y, Pervushin K, Verma C, Beuerman RW. Li J, et al. Among authors: lakshminarayanan r. Biochim Biophys Acta. 2013 Mar;1828(3):1112-21. doi: 10.1016/j.bbamem.2012.12.015. Epub 2012 Dec 26. Biochim Biophys Acta. 2013. PMID: 23274275 Free article.

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