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A novel anti-CD146 antibody specifically targets cancer cells by internalizing the molecule.
Nollet M, Stalin J, Moyon A, Traboulsi W, Essaadi A, Robert S, Malissen N, Bachelier R, Daniel L, Foucault-Bertaud A, Gaudy-Marqueste C, Lacroix R, Leroyer AS, Guillet B, Bardin N, Dignat-George F, Blot-Chabaud M. Nollet M, et al. Among authors: essaadi a. Oncotarget. 2017 Nov 28;8(68):112283-112296. doi: 10.18632/oncotarget.22736. eCollection 2017 Dec 22. Oncotarget. 2017. PMID: 29348825 Free PMC article.
Soluble CD146 boosts therapeutic effect of endothelial progenitors through proteolytic processing of short CD146 isoform.
Stalin J, Harhouri K, Hubert L, Garrigue P, Nollet M, Essaadi A, Muller A, Foucault-Bertaud A, Bachelier R, Sabatier F, Pisano P, Peiretti F, Leroyer AS, Guillet B, Bardin N, Dignat-George F, Blot-Chabaud M. Stalin J, et al. Among authors: essaadi a. Cardiovasc Res. 2016 Aug 1;111(3):240-51. doi: 10.1093/cvr/cvw096. Epub 2016 May 11. Cardiovasc Res. 2016. PMID: 27170199
Targeting soluble CD146 with a neutralizing antibody inhibits vascularization, growth and survival of CD146-positive tumors.
Stalin J, Nollet M, Garigue P, Fernandez S, Vivancos L, Essaadi A, Muller A, Bachelier R, Foucault-Bertaud A, Fugazza L, Leroyer AS, Bardin N, Guillet B, Dignat-George F, Blot-Chabaud M. Stalin J, et al. Among authors: essaadi a. Oncogene. 2016 Oct 20;35(42):5489-5500. doi: 10.1038/onc.2016.83. Epub 2016 Apr 11. Oncogene. 2016. PMID: 27065325