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332 results

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Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output.
Baghdasaryan A, Claudel T, Gumhold J, Silbert D, Adorini L, Roda A, Vecchiotti S, Gonzalez FJ, Schoonjans K, Strazzabosco M, Fickert P, Trauner M. Baghdasaryan A, et al. Among authors: adorini l. Hepatology. 2011 Oct;54(4):1303-12. doi: 10.1002/hep.24537. Hepatology. 2011. PMID: 22006858 Free PMC article.
Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease.
Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M, Adorini L, Sciacca CI, Clopton P, Castelloe E, Dillon P, Pruzanski M, Shapiro D. Mudaliar S, et al. Among authors: adorini l. Gastroenterology. 2013 Sep;145(3):574-82.e1. doi: 10.1053/j.gastro.2013.05.042. Epub 2013 May 30. Gastroenterology. 2013. PMID: 23727264 Clinical Trial.
Cardiopulmonary protective effects of the selective FXR agonist obeticholic acid in the rat model of monocrotaline-induced pulmonary hypertension.
Vignozzi L, Morelli A, Cellai I, Filippi S, Comeglio P, Sarchielli E, Maneschi E, Vannelli GB, Adorini L, Maggi M. Vignozzi L, et al. Among authors: adorini l. J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):277-292. doi: 10.1016/j.jsbmb.2016.07.004. Epub 2016 Jul 15. J Steroid Biochem Mol Biol. 2017. PMID: 27425465
Anti-fibrotic effects of chronic treatment with the selective FXR agonist obeticholic acid in the bleomycin-induced rat model of pulmonary fibrosis.
Comeglio P, Filippi S, Sarchielli E, Morelli A, Cellai I, Corcetto F, Corno C, Maneschi E, Pini A, Adorini L, Vannelli GB, Maggi M, Vignozzi L. Comeglio P, et al. Among authors: adorini l. J Steroid Biochem Mol Biol. 2017 Apr;168:26-37. doi: 10.1016/j.jsbmb.2017.01.010. Epub 2017 Jan 20. J Steroid Biochem Mol Biol. 2017. PMID: 28115235
A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis.
Kowdley KV, Luketic V, Chapman R, Hirschfield GM, Poupon R, Schramm C, Vincent C, Rust C, Parés A, Mason A, Marschall HU, Shapiro D, Adorini L, Sciacca C, Beecher-Jones T, Böhm O, Pencek R, Jones D; Obeticholic Acid PBC Monotherapy Study Group. Kowdley KV, et al. Among authors: adorini l. Hepatology. 2018 May;67(5):1890-1902. doi: 10.1002/hep.29569. Epub 2018 Jan 29. Hepatology. 2018. PMID: 29023915 Free PMC article. Clinical Trial.
FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid.
Friedman ES, Li Y, Shen TD, Jiang J, Chau L, Adorini L, Babakhani F, Edwards J, Shapiro D, Zhao C, Carr RM, Bittinger K, Li H, Wu GD. Friedman ES, et al. Among authors: adorini l. Gastroenterology. 2018 Dec;155(6):1741-1752.e5. doi: 10.1053/j.gastro.2018.08.022. Epub 2018 Aug 23. Gastroenterology. 2018. PMID: 30144429 Free PMC article. Clinical Trial.
332 results