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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.
Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR. Bago R, et al. Among authors: prescott ar. Biochem J. 2014 Nov 1;463(3):413-27. doi: 10.1042/BJ20140889. Biochem J. 2014. PMID: 25177796 Free PMC article.
Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM. Kazlauskaite A, et al. Among authors: prescott ar. EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25. EMBO Rep. 2015. PMID: 26116755 Free PMC article.
mito-QC illuminates mitophagy and mitochondrial architecture in vivo.
McWilliams TG, Prescott AR, Allen GF, Tamjar J, Munson MJ, Thomson C, Muqit MM, Ganley IG. McWilliams TG, et al. Among authors: prescott ar. J Cell Biol. 2016 Aug 1;214(3):333-45. doi: 10.1083/jcb.201603039. Epub 2016 Jul 25. J Cell Biol. 2016. PMID: 27458135 Free PMC article.
Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK. McWilliams TG, et al. Among authors: prescott ar. Open Biol. 2018 Nov 7;8(11):180108. doi: 10.1098/rsob.180108. Open Biol. 2018. PMID: 30404819 Free PMC article.
A comparative map of macroautophagy and mitophagy in the vertebrate eye.
McWilliams TG, Prescott AR, Villarejo-Zori B, Ball G, Boya P, Ganley IG. McWilliams TG, et al. Among authors: prescott ar. Autophagy. 2019 Jul;15(7):1296-1308. doi: 10.1080/15548627.2019.1580509. Epub 2019 Feb 20. Autophagy. 2019. PMID: 30786807 Free PMC article.
FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning.
Fulcher LJ, He Z, Mei L, Macartney TJ, Wood NT, Prescott AR, Whigham AJ, Varghese J, Gourlay R, Ball G, Clarke R, Campbell DG, Maxwell CA, Sapkota GP. Fulcher LJ, et al. Among authors: prescott ar. EMBO Rep. 2019 Sep;20(9):e47495. doi: 10.15252/embr.201847495. Epub 2019 Jul 24. EMBO Rep. 2019. PMID: 31338967 Free PMC article.
210 results