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In vivo potent BM635 analogue with improved drug-like properties.
Poce G, Cocozza M, Alfonso S, Consalvi S, Venditti G, Fernandez-Menendez R, Bates RH, Barros Aguirre D, Ballell L, De Logu A, Vistoli G, Biava M. Poce G, et al. Among authors: cocozza m. Eur J Med Chem. 2018 Feb 10;145:539-550. doi: 10.1016/j.ejmech.2017.12.075. Epub 2017 Dec 27. Eur J Med Chem. 2018. PMID: 29335214
Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection.
Poce G, Bates RH, Alfonso S, Cocozza M, Porretta GC, Ballell L, Rullas J, Ortega F, De Logu A, Agus E, La Rosa V, Pasca MR, De Rossi E, Wae B, Franzblau SG, Manetti F, Botta M, Biava M. Poce G, et al. Among authors: cocozza m. PLoS One. 2013;8(2):e56980. doi: 10.1371/journal.pone.0056980. Epub 2013 Feb 21. PLoS One. 2013. PMID: 23437287 Free PMC article.
Pharmaceutical salt of BM635 with improved bioavailability.
Poce G, Consalvi S, Cocozza M, Fernandez-Menendez R, Bates RH, Ortega Muro F, Barros Aguirre D, Ballell L, Biava M. Poce G, et al. Among authors: cocozza m. Eur J Pharm Sci. 2017 Mar 1;99:17-23. doi: 10.1016/j.ejps.2016.12.003. Epub 2016 Dec 8. Eur J Pharm Sci. 2017. PMID: 27939618
Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography.
Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta GC, Colotti G, Biava M, Moraca F, Botta M, Yardley V, Fiorillo A, Lantella A, Malatesta F, Ilari A. Baiocco P, et al. Among authors: cocozza m. ChemMedChem. 2013 Jul;8(7):1175-83. doi: 10.1002/cmdc.201300176. Epub 2013 Jun 3. ChemMedChem. 2013. PMID: 23733388
52 results