Rothwell PJ - Search Results

1

Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model.

Allen A, Wang C, Caproni LJ, Sugiyarto G, Harden E, Douglas LR, Duriez PJ, Karbowniczek K, Extance J, Rothwell PJ, Orefo I, Tite JP, Stevenson FK, Ottensmeier CH, Savelyeva N. Allen A, et al. Among authors: rothwell pj. Cancer Immunol Immunother. 2018 Apr;67(4):627-638. doi: 10.1007/s00262-017-2111-y. Epub 2018 Jan 12. Cancer Immunol Immunother. 2018. PMID: 29330557 Free PMC article.

2

Novel synthetic plasmid and Doggybone DNA vaccines induce neutralizing antibodies and provide protection from lethal influenza challenge in mice.

Scott VL, Patel A, Villarreal DO, Hensley SE, Ragwan E, Yan J, Sardesai NY, Rothwell PJ, Extance JP, Caproni LJ, Weiner DB. Scott VL, et al. Among authors: rothwell pj. Hum Vaccin Immunother. 2015;11(8):1972-82. doi: 10.1080/21645515.2015.1022008. Hum Vaccin Immunother. 2015. PMID: 26091432 Free PMC article.

3

dbDNA™: An advanced platform for genetic medicines.

Adie T, Orefo I, Kysh D, Kondas K, Thapa S, Extance J, Duncan T, Rothwell PJ. Adie T, et al. Among authors: rothwell pj. Drug Discov Today. 2022 Feb;27(2):374-377. doi: 10.1016/j.drudis.2021.09.018. Epub 2021 Sep 30. Drug Discov Today. 2022. PMID: 34601125

4

A pre-equilibrium before nucleotide binding limits fingers subdomain closure by Klentaq1.

Rothwell PJ, Waksman G. Rothwell PJ, et al. J Biol Chem. 2007 Sep 28;282(39):28884-28892. doi: 10.1074/jbc.M704824200. Epub 2007 Jul 18. J Biol Chem. 2007. PMID: 17640877 Free article.

5

dNTP-dependent conformational transitions in the fingers subdomain of Klentaq1 DNA polymerase: insights into the role of the "nucleotide-binding" state.

Rothwell PJ, Allen WJ, Sisamakis E, Kalinin S, Felekyan S, Widengren J, Waksman G, Seidel CA. Rothwell PJ, et al. J Biol Chem. 2013 May 10;288(19):13575-91. doi: 10.1074/jbc.M112.432690. Epub 2013 Mar 22. J Biol Chem. 2013. PMID: 23525110 Free PMC article.

6

Motions of the fingers subdomain of klentaq1 are fast and not rate limiting: implications for the molecular basis of fidelity in DNA polymerases.

Rothwell PJ, Mitaksov V, Waksman G. Rothwell PJ, et al. Mol Cell. 2005 Aug 5;19(3):345-55. doi: 10.1016/j.molcel.2005.06.032. Mol Cell. 2005. PMID: 16061181 Free article.

7

Structure and mechanism of DNA polymerases.

Rothwell PJ, Waksman G. Rothwell PJ, et al. Adv Protein Chem. 2005;71:401-40. doi: 10.1016/S0065-3233(04)71011-6. Adv Protein Chem. 2005. PMID: 16230118 Review.

8

An intramolecular FRET system monitors fingers subdomain opening in Klentaq1.

Allen WJ, Rothwell PJ, Waksman G. Allen WJ, et al. Among authors: rothwell pj. Protein Sci. 2008 Mar;17(3):401-8. doi: 10.1110/ps.073309208. Protein Sci. 2008. PMID: 18287276 Free PMC article.

9

Accurate single-molecule FRET studies using multiparameter fluorescence detection.

Sisamakis E, Valeri A, Kalinin S, Rothwell PJ, Seidel CA. Sisamakis E, et al. Among authors: rothwell pj. Methods Enzymol. 2010;475:455-514. doi: 10.1016/S0076-6879(10)75018-7. Methods Enzymol. 2010. PMID: 20627168

10

Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA.

Cristóvão M, Sisamakis E, Hingorani MM, Marx AD, Jung CP, Rothwell PJ, Seidel CA, Friedhoff P. Cristóvão M, et al. Among authors: rothwell pj. Nucleic Acids Res. 2012 Jul;40(12):5448-64. doi: 10.1093/nar/gks138. Epub 2012 Feb 24. Nucleic Acids Res. 2012. PMID: 22367846 Free PMC article.

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