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A threonyl-tRNA synthetase-mediated translation initiation machinery.
Jeong SJ, Park S, Nguyen LT, Hwang J, Lee EY, Giong HK, Lee JS, Yoon I, Lee JH, Kim JH, Kim HK, Kim D, Yang WS, Kim SY, Lee CY, Yu K, Sonenberg N, Kim MH, Kim S. Jeong SJ, et al. Among authors: kim hk, kim d, kim sy, kim s, kim mh, kim jh. Nat Commun. 2019 Mar 22;10(1):1357. doi: 10.1038/s41467-019-09086-0. Nat Commun. 2019. PMID: 30902983 Free PMC article.
Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors.
Yoon S, Kim JH, Kim SE, Kim C, Tran PT, Ann J, Koh Y, Jang J, Kim S, Moon HS, Kim WK, Lee S, Lee J, Kim S, Lee J. Yoon S, et al. Among authors: kim se, kim wk, kim c, kim s, kim jh. J Med Chem. 2016 Nov 23;59(22):10322-10328. doi: 10.1021/acs.jmedchem.6b01190. Epub 2016 Nov 9. J Med Chem. 2016. PMID: 27933890
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.
Kim JH, Lee C, Lee M, Wang H, Kim K, Park SJ, Yoon I, Jang J, Zhao H, Kim HK, Kwon NH, Jeong SJ, Yoo HC, Kim JH, Yang JS, Lee MY, Lee CW, Yun J, Oh SJ, Kang JS, Martinis SA, Hwang KY, Guo M, Han G, Han JM, Kim S. Kim JH, et al. Among authors: kim hk, kim s, kim k. Nat Commun. 2017 Sep 29;8(1):732. doi: 10.1038/s41467-017-00785-0. Nat Commun. 2017. PMID: 28963468 Free PMC article.
Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).
Yoon S, Kim SE, Kim JH, Yoon I, Tran PT, Ann J, Kim C, Byun WS, Lee S, Kim S, Lee J, Lee J. Yoon S, et al. Among authors: kim se, kim c, kim s, kim jh. Bioorg Med Chem. 2019 Mar 15;27(6):1099-1109. doi: 10.1016/j.bmc.2019.01.037. Epub 2019 Jan 30. Bioorg Med Chem. 2019. PMID: 30755350
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