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αβ,α'β'-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes.
Chem Commun (Camb). 2023 Oct 26;59(86):12859-12862. doi: 10.1039/d3cc02932h.
Chem Commun (Camb). 2023.
PMID: 37815791
Free PMC article.
High-throughput screen with the l,d-transpeptidase LdtMt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.
de Munnik M, Lang PA, De Dios Anton F, Cacho M, Bates RH, Brem J, Rodríguez Miquel B, Schofield CJ.
de Munnik M, et al.
Chem Sci. 2023 May 30;14(26):7262-7278. doi: 10.1039/d2sc06858c. eCollection 2023 Jul 5.
Chem Sci. 2023.
PMID: 37416715
Free PMC article.
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Extending the diversity of Myceliophthora thermophila LPMOs: Two different xyloglucan cleavage profiles.
Sun P, de Munnik M, van Berkel WJH, Kabel MA.
Sun P, et al. Among authors: de munnik m.
Carbohydr Polym. 2022 Jul 15;288:119373. doi: 10.1016/j.carbpol.2022.119373. Epub 2022 Mar 18.
Carbohydr Polym. 2022.
PMID: 35450635
Free article.
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Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen.
de Munnik M , Lohans CT , Lang PA , Langley GW , Malla TR , Tumber A , Schofield CJ , Brem J .
de Munnik M , et al.
Chem Commun (Camb). 2019 Aug 22;55(69):10214-10217. doi: 10.1039/c9cc04145a.
Chem Commun (Camb). 2019.
PMID: 31380528
Free PMC article.
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A Fluorescence-Based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2.
de Munnik M, Lohans CT, Langley GW, Bon C, Brem J, Schofield CJ.
de Munnik M, et al.
Chembiochem. 2020 Feb 3;21(3):368-372. doi: 10.1002/cbic.201900379. Epub 2019 Nov 8.
Chembiochem. 2020.
PMID: 31322798
Free PMC article.
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Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants.
Lohans CT, Chan HTH, Malla TR, Kumar K, Kamps JJAG, McArdle DJB, van Groesen E, de Munnik M, Tooke CL, Spencer J, Paton RS, Brem J, Schofield CJ.
Lohans CT, et al. Among authors: de munnik m.
Angew Chem Int Ed Engl. 2019 Feb 11;58(7):1990-1994. doi: 10.1002/anie.201809424. Epub 2019 Jan 21.
Angew Chem Int Ed Engl. 2019.
PMID: 30569575
Free PMC article.
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Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines.
Rainoldi G, Begnini F, de Munnik M, Lo Presti L, Vande Velde CML, Orru R, Lesma G, Ruijter E, Silvani A.
Rainoldi G, et al. Among authors: de munnik m.
ACS Comb Sci. 2018 Feb 12;20(2):98-105. doi: 10.1021/acscombsci.7b00179. Epub 2018 Jan 25.
ACS Comb Sci. 2018.
PMID: 29323868
Free article.
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