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PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.
Civiero L, Cogo S, Kiekens A, Morganti C, Tessari I, Lobbestael E, Baekelandt V, Taymans JM, Chartier-Harlin MC, Franchin C, Arrigoni G, Lewis PA, Piccoli G, Bubacco L, Cookson MR, Pinton P, Greggio E. Civiero L, et al. Among authors: piccoli g. Front Mol Neurosci. 2017 Dec 14;10:417. doi: 10.3389/fnmol.2017.00417. eCollection 2017. Front Mol Neurosci. 2017. PMID: 29311810 Free PMC article.
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex.
Cirnaru MD, Marte A, Belluzzi E, Russo I, Gabrielli M, Longo F, Arcuri L, Murru L, Bubacco L, Matteoli M, Fedele E, Sala C, Passafaro M, Morari M, Greggio E, Onofri F, Piccoli G. Cirnaru MD, et al. Among authors: piccoli g. Front Mol Neurosci. 2014 May 27;7:49. doi: 10.3389/fnmol.2014.00049. eCollection 2014. Front Mol Neurosci. 2014. PMID: 24904275 Free PMC article.
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Civiero L, Cirnaru MD, Beilina A, Rodella U, Russo I, Belluzzi E, Lobbestael E, Reyniers L, Hondhamuni G, Lewis PA, Van den Haute C, Baekelandt V, Bandopadhyay R, Bubacco L, Piccoli G, Cookson MR, Taymans JM, Greggio E. Civiero L, et al. Among authors: piccoli g. J Neurochem. 2015 Dec;135(6):1242-56. doi: 10.1111/jnc.13369. Epub 2015 Oct 19. J Neurochem. 2015. PMID: 26375402 Free PMC article.
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
Belluzzi E, Gonnelli A, Cirnaru MD, Marte A, Plotegher N, Russo I, Civiero L, Cogo S, Carrion MP, Franchin C, Arrigoni G, Beltramini M, Bubacco L, Onofri F, Piccoli G, Greggio E. Belluzzi E, et al. Among authors: piccoli g. Mol Neurodegener. 2016 Jan 13;11:1. doi: 10.1186/s13024-015-0066-z. Mol Neurodegener. 2016. PMID: 26758690 Free PMC article.
LRRK2 Regulates Voltage-Gated Calcium Channel Function.
Bedford C, Sears C, Perez-Carrion M, Piccoli G, Condliffe SB. Bedford C, et al. Among authors: piccoli g. Front Mol Neurosci. 2016 May 23;9:35. doi: 10.3389/fnmol.2016.00035. eCollection 2016. Front Mol Neurosci. 2016. PMID: 27242426 Free PMC article.
The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.
Perez Carrion M, Pischedda F, Biosa A, Russo I, Straniero L, Civiero L, Guida M, Gloeckner CJ, Ticozzi N, Tiloca C, Mariani C, Pezzoli G, Duga S, Pichler I, Pan L, Landers JE, Greggio E, Hess MW, Goldwurm S, Piccoli G. Perez Carrion M, et al. Among authors: piccoli g. Front Mol Neurosci. 2018 Feb 28;11:64. doi: 10.3389/fnmol.2018.00064. eCollection 2018. Front Mol Neurosci. 2018. PMID: 29541021 Free PMC article.
Levetiracetam treatment ameliorates LRRK2 pathological mutant phenotype.
Rassu M, Biosa A, Galioto M, Fais M, Sini P, Greggio E, Piccoli G, Crosio C, Iaccarino C. Rassu M, et al. Among authors: piccoli g. J Cell Mol Med. 2019 Dec;23(12):8505-8510. doi: 10.1111/jcmm.14674. Epub 2019 Sep 27. J Cell Mol Med. 2019. PMID: 31560168 Free PMC article.
Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions.
Obergasteiger J, Frapporti G, Lamonaca G, Pizzi S, Picard A, Lavdas AA, Pischedda F, Piccoli G, Hilfiker S, Lobbestael E, Baekelandt V, Hicks AA, Corti C, Pramstaller PP, Volta M. Obergasteiger J, et al. Among authors: piccoli g. Cell Death Discov. 2020 Jun 8;6:45. doi: 10.1038/s41420-020-0279-y. eCollection 2020. Cell Death Discov. 2020. PMID: 32550012 Free PMC article.
962 results