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Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies.
Front Neurosci. 2017 Dec 22;11:724. doi: 10.3389/fnins.2017.00724. eCollection 2017.
Front Neurosci. 2017.
PMID: 29311797
Free PMC article.
Review.
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.
Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM Jr, Dickey CA.
Fontaine SN, et al.
EMBO J. 2016 Jul 15;35(14):1537-49. doi: 10.15252/embj.201593489. Epub 2016 Jun 3.
EMBO J. 2016.
PMID: 27261198
Free PMC article.
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Human cyclophilin 40 unravels neurotoxic amyloids.
Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, Zweckstetter M, Dickey CA, Koren J 3rd, Blair LJ.
Baker JD, et al. Among authors: shelton lb.
PLoS Biol. 2017 Jun 27;15(6):e2001336. doi: 10.1371/journal.pbio.2001336. eCollection 2017 Jun.
PLoS Biol. 2017.
PMID: 28654636
Free PMC article.
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Hsp90 activator Aha1 drives production of pathological tau aggregates.
Shelton LB, Baker JD, Zheng D, Sullivan LE, Solanki PK, Webster JM, Sun Z, Sabbagh JJ, Nordhues BA, Koren J 3rd, Ghosh S, Blagg BSJ, Blair LJ, Dickey CA.
Shelton LB, et al.
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9707-9712. doi: 10.1073/pnas.1707039114. Epub 2017 Aug 21.
Proc Natl Acad Sci U S A. 2017.
PMID: 28827321
Free PMC article.
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FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model.
Criado-Marrero M, Gebru NT, Gould LA, Blazier DM, Vidal-Aguiar Y, Smith TM, Abdelmaboud SS, Shelton LB, Wang X, Dahrendorff J, Beaulieu-Abdelahad D, Dickey CA, Blair LJ.
Criado-Marrero M, et al. Among authors: shelton lb.
NPJ Aging Mech Dis. 2021 May 3;7(1):9. doi: 10.1038/s41514-021-00062-x.
NPJ Aging Mech Dis. 2021.
PMID: 33941782
Free PMC article.
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Noncontact Rotational Head Injury Produces Transient Cognitive Deficits but Lasting Neuropathological Changes.
Sabbagh JJ, Fontaine SN, Shelton LB, Blair LJ, Hunt JB Jr, Zhang B, Gutmann JM, Lee DC, Lloyd JD, Dickey CA.
Sabbagh JJ, et al. Among authors: shelton lb.
J Neurotrauma. 2016 Oct 1;33(19):1751-1760. doi: 10.1089/neu.2015.4288. Epub 2016 Mar 16.
J Neurotrauma. 2016.
PMID: 26739819
Free PMC article.
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Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.
Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki JE, Dickey CA.
Martin MD, et al. Among authors: shelton lb.
ACS Chem Biol. 2016 Jul 15;11(7):2041-8. doi: 10.1021/acschembio.6b00223. Epub 2016 May 26.
ACS Chem Biol. 2016.
PMID: 27177119
Free PMC article.
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