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Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.
Aghazadeh Tabrizi M, Baraldi PG, Baraldi S, Ruggiero E, De Stefano L, Rizzolio F, Di Cesare Mannelli L, Ghelardini C, Chicca A, Lapillo M, Gertsch J, Manera C, Macchia M, Martinelli A, Granchi C, Minutolo F, Tuccinardi T. Aghazadeh Tabrizi M, et al. Among authors: gertsch j. J Med Chem. 2018 Feb 8;61(3):1340-1354. doi: 10.1021/acs.jmedchem.7b01845. Epub 2018 Jan 22. J Med Chem. 2018. PMID: 29309142
Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.
Pfeiffer B, Hauenstein K, Merz P, Gertsch J, Altmann KH. Pfeiffer B, et al. Among authors: gertsch j. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3760-3. doi: 10.1016/j.bmcl.2009.04.112. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19433359
Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors.
Yang P, Myint KZ, Tong Q, Feng R, Cao H, Almehizia AA, Alqarni MH, Wang L, Bartlow P, Gao Y, Gertsch J, Teramachi J, Kurihara N, Roodman GD, Cheng T, Xie XQ. Yang P, et al. Among authors: gertsch j. J Med Chem. 2012 Nov 26;55(22):9973-87. doi: 10.1021/jm301212u. Epub 2012 Oct 31. J Med Chem. 2012. PMID: 23072339 Free PMC article.
218 results