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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll FI, Stevens RC, Cherezov V, Katritch V, Wacker D, Roth BL. Che T, et al. Among authors: strachan rt. Cell. 2018 Jan 11;172(1-2):55-67.e15. doi: 10.1016/j.cell.2017.12.011. Epub 2018 Jan 4. Cell. 2018. PMID: 29307491 Free PMC article.
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.
Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. Staus DP, et al. Among authors: strachan rt. Nature. 2016 Jul 21;535(7612):448-52. doi: 10.1038/nature18636. Epub 2016 Jul 13. Nature. 2016. PMID: 27409812 Free PMC article.
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.
English JG, Olsen RHJ, Lansu K, Patel M, White K, Cockrell AS, Singh D, Strachan RT, Wacker D, Roth BL. English JG, et al. Among authors: strachan rt. Cell. 2019 Jul 25;178(3):748-761.e17. doi: 10.1016/j.cell.2019.05.051. Epub 2019 Jul 4. Cell. 2019. PMID: 31280962 Free PMC article.
VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.
English JG, Olsen RHJ, Lansu K, Patel M, White K, Cockrell AS, Singh D, Strachan RT, Wacker D, Roth BL. English JG, et al. Among authors: strachan rt. Cell. 2019 Aug 8;178(4):1030. doi: 10.1016/j.cell.2019.07.036. Cell. 2019. PMID: 31398329 Free PMC article. No abstract available.
Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors.
Foster SR, Hauser AS, Vedel L, Strachan RT, Huang XP, Gavin AC, Shah SD, Nayak AP, Haugaard-Kedström LM, Penn RB, Roth BL, Bräuner-Osborne H, Gloriam DE. Foster SR, et al. Among authors: strachan rt. Cell. 2019 Oct 31;179(4):895-908.e21. doi: 10.1016/j.cell.2019.10.010. Cell. 2019. PMID: 31675498 Free PMC article.
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome.
Olsen RHJ, DiBerto JF, English JG, Glaudin AM, Krumm BE, Slocum ST, Che T, Gavin AC, McCorvy JD, Roth BL, Strachan RT. Olsen RHJ, et al. Among authors: strachan rt. Nat Chem Biol. 2020 Aug;16(8):841-849. doi: 10.1038/s41589-020-0535-8. Epub 2020 May 4. Nat Chem Biol. 2020. PMID: 32367019 Free PMC article.
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor.
Levit Kaplan A, Strachan RT, Braz JM, Craik V, Slocum S, Mangano T, Amabo V, O'Donnell H, Lak P, Basbaum AI, Roth BL, Shoichet BK. Levit Kaplan A, et al. Among authors: strachan rt. J Med Chem. 2022 Mar 10;65(5):4201-4217. doi: 10.1021/acs.jmedchem.1c02031. Epub 2022 Feb 23. J Med Chem. 2022. PMID: 35195401 Free PMC article.
32 results