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Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.
Kalin JH, Wu M, Gomez AV, Song Y, Das J, Hayward D, Adejola N, Wu M, Panova I, Chung HJ, Kim E, Roberts HJ, Roberts JM, Prusevich P, Jeliazkov JR, Roy Burman SS, Fairall L, Milano C, Eroglu A, Proby CM, Dinkova-Kostova AT, Hancock WW, Gray JJ, Bradner JE, Valente S, Mai A, Anders NM, Rudek MA, Hu Y, Ryu B, Schwabe JWR, Mattevi A, Alani RM, Cole PA. Kalin JH, et al. Among authors: alani rm. Nat Commun. 2018 Jan 4;9(1):53. doi: 10.1038/s41467-017-02242-4. Nat Commun. 2018. PMID: 29302039 Free PMC article.
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.
Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, Bernstein BE, Alani R, Golub TR, Cole PA, Filbin MG, Shi Y. Anastas JN, et al. Cancer Cell. 2019 Nov 11;36(5):528-544.e10. doi: 10.1016/j.ccell.2019.09.005. Epub 2019 Oct 17. Cancer Cell. 2019. PMID: 31631026 Free article.
MicroRNAs as an emerging target for melanoma therapy.
Ryu B, Hwang S, Alani RM. Ryu B, et al. Among authors: alani rm. J Invest Dermatol. 2013 May;133(5):1137-9. doi: 10.1038/jid.2012.505. J Invest Dermatol. 2013. PMID: 23594536 Free article.
Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells.
Yan G, Eller MS, Elm C, Larocca CA, Ryu B, Panova IP, Dancy BM, Bowers EM, Meyers D, Lareau L, Cole PA, Taverna SD, Alani RM. Yan G, et al. Among authors: alani rm. J Invest Dermatol. 2013 Oct;133(10):2444-2452. doi: 10.1038/jid.2013.187. Epub 2013 Apr 18. J Invest Dermatol. 2013. PMID: 23698071 Free PMC article.
Emerging Biomarkers in Cutaneous Melanoma.
Eisenstein A, Gonzalez EC, Raghunathan R, Xu X, Wu M, McLean EO, McGee J, Ryu B, Alani RM. Eisenstein A, et al. Among authors: alani rm. Mol Diagn Ther. 2018 Apr;22(2):203-218. doi: 10.1007/s40291-018-0318-z. Mol Diagn Ther. 2018. PMID: 29411301 Review.
Selective HAT inhibitors as mechanistic tools for protein acetylation.
Zheng Y, Thompson PR, Cebrat M, Wang L, Devlin MK, Alani RM, Cole PA. Zheng Y, et al. Among authors: alani rm. Methods Enzymol. 2004;376:188-99. doi: 10.1016/S0076-6879(03)76012-1. Methods Enzymol. 2004. PMID: 14975306 Review. No abstract available.
94 results