Moroco JA - Search Results

1

Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.

Moroco JA, Alvarado JJ, Staudt RP, Shi H, Wales TE, Smithgall TE, Engen JR. Moroco JA, et al. J Mol Biol. 2018 Feb 2;430(3):310-321. doi: 10.1016/j.jmb.2017.12.008. Epub 2017 Dec 16. J Mol Biol. 2018. PMID: 29258818 Free PMC article.

2

Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism.

Alvarado JJ, Betts L, Moroco JA, Smithgall TE, Yeh JI. Alvarado JJ, et al. Among authors: moroco ja. J Biol Chem. 2010 Nov 12;285(46):35455-61. doi: 10.1074/jbc.M110.145102. Epub 2010 Sep 1. J Biol Chem. 2010. PMID: 20810664 Free PMC article.

3

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.

Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE. Pene-Dumitrescu T, et al. Among authors: moroco ja. BMC Chem Biol. 2012 Mar 15;12:1. doi: 10.1186/1472-6769-12-1. BMC Chem Biol. 2012. PMID: 22420777 Free PMC article.

4

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement.

Moroco JA, Craigo JK, Iacob RE, Wales TE, Engen JR, Smithgall TE. Moroco JA, et al. PLoS One. 2014 Aug 21;9(8):e105629. doi: 10.1371/journal.pone.0105629. eCollection 2014. PLoS One. 2014. PMID: 25144189 Free PMC article.

5

A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region.

Moroco JA, Baumgartner MP, Rust HL, Choi HG, Hur W, Gray NS, Camacho CJ, Smithgall TE. Moroco JA, et al. Chem Biol Drug Des. 2015 Aug;86(2):144-55. doi: 10.1111/cbdd.12473. Epub 2014 Nov 28. Chem Biol Drug Des. 2015. PMID: 25376742 Free PMC article.

6

The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.

Shen K, Moroco JA, Patel RK, Shi H, Engen JR, Dorman HR, Smithgall TE. Shen K, et al. Among authors: moroco ja. Sci Signal. 2018 Oct 23;11(553):eaat5916. doi: 10.1126/scisignal.aat5916. Sci Signal. 2018. PMID: 30352950

7

ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr.

Du S, Alvarado JJ, Wales TE, Moroco JA, Engen JR, Smithgall TE. Du S, et al. Among authors: moroco ja. Structure. 2022 Nov 3;30(11):1508-1517.e3. doi: 10.1016/j.str.2022.08.008. Epub 2022 Sep 16. Structure. 2022. PMID: 36115344 Free PMC article.

8

Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.

Lee J, Su EW, Zhu C, Hainline S, Phuah J, Moroco JA, Smithgall TE, Kuchroo VK, Kane LP. Lee J, et al. Among authors: moroco ja. Mol Cell Biol. 2011 Oct;31(19):3963-74. doi: 10.1128/MCB.05297-11. Epub 2011 Aug 1. Mol Cell Biol. 2011. PMID: 21807895 Free PMC article.

9

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding.

Kardon JR, Moroco JA, Engen JR, Baker TA. Kardon JR, et al. Among authors: moroco ja. Elife. 2020 Feb 24;9:e54387. doi: 10.7554/eLife.54387. Elife. 2020. PMID: 32091391 Free PMC article.

10

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.

Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD. Mourtada R, et al. Among authors: moroco ja. Nat Biotechnol. 2019 Oct;37(10):1186-1197. doi: 10.1038/s41587-019-0222-z. Epub 2019 Aug 19. Nat Biotechnol. 2019. PMID: 31427820 Free PMC article.

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