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Action mechanism of naphthofuranquinones against fluconazole-resistant Candida tropicalis strains evidenced by proteomic analysis: The role of increased endogenous ROS.
de Andrade Neto JB, da Silva CR, Campos RS, do Nascimento FBSA, Sampaio LS, da Silva AR, Josino MAA, de Moraes MO, Lobo MDP, Moreno FBMB, Moreira ACOM, de Azevedo Moreira R, Grangeiro TB, da Silva Júnior EN, Magalhães HIF, Rocha DD, Cavalcanti BC, Júnior HVN. de Andrade Neto JB, et al. Among authors: da silva ar, da silva cr, junior hvn, da silva junior en. Microb Pathog. 2018 Apr;117:32-42. doi: 10.1016/j.micpath.2017.12.016. Epub 2017 Dec 8. Microb Pathog. 2018. PMID: 29229505 Free article.
Preclinical genotoxicology of nor-β-lapachone in human cultured lymphocytes and Chinese hamster lung fibroblasts.
Cavalcanti BC, Barros FW, Cabral IO, Ferreira JR, Magalhães HI, Júnior HV, da Silva Júnior EN, de Abreu FC, Costa CO, Goulart MO, Moraes MO, Pessoa C. Cavalcanti BC, et al. Among authors: da silva junior en, junior hv. Chem Res Toxicol. 2011 Sep 19;24(9):1560-74. doi: 10.1021/tx200180y. Epub 2011 Aug 23. Chem Res Toxicol. 2011. PMID: 21830773
Growth inhibitory effects of 3'-nitro-3-phenylamino nor-beta-lapachone against HL-60: a redox-dependent mechanism.
Araújo AJ, de Souza AA, da Silva Júnior EN, Marinho-Filho JD, de Moura MA, Rocha DD, Vasconcellos MC, Costa CO, Pessoa C, de Moraes MO, Ferreira VF, de Abreu FC, Pinto AV, Montenegro RC, Costa-Lotufo LV, Goulart MO. Araújo AJ, et al. Among authors: da silva junior en. Toxicol In Vitro. 2012 Jun;26(4):585-94. doi: 10.1016/j.tiv.2012.02.003. Epub 2012 Feb 22. Toxicol In Vitro. 2012. PMID: 22386657 Free article.
1,2,3-triazole-, arylamino- and thio-substituted 1,4-naphthoquinones: potent antitumor activity, electrochemical aspects, and bioisosteric replacement of C-ring-modified lapachones.
da Cruz EH, Hussene CM, Dias GG, Diogo EB, de Melo IM, Rodrigues BL, da Silva MG, Valença WO, Camara CA, de Oliveira RN, de Paiva YG, Goulart MO, Cavalcanti BC, Pessoa C, da Silva Júnior EN. da Cruz EH, et al. Among authors: da silva junior en, da silva mg. Bioorg Med Chem. 2014 Mar 1;22(5):1608-19. doi: 10.1016/j.bmc.2014.01.033. Epub 2014 Jan 31. Bioorg Med Chem. 2014. PMID: 24530030 Free article.
Antifungal activity of naphthoquinoidal compounds in vitro against fluconazole-resistant strains of different Candida species: a special emphasis on mechanisms of action on Candida tropicalis.
Neto JB, da Silva CR, Neta MA, Campos RS, Siebra JT, Silva RA, Gaspar DM, Magalhães HI, de Moraes MO, Lobo MD, Grangeiro TB, Carvalho TS, Diogo EB, da Silva Júnior EN, Rodrigues FA, Cavalcanti BC, Júnior HV. Neto JB, et al. Among authors: da silva cr, silva ra, da silva junior en, junior hv. PLoS One. 2014 May 9;9(5):e93698. doi: 10.1371/journal.pone.0093698. eCollection 2014. PLoS One. 2014. PMID: 24817320 Free PMC article.
Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.
da Cruz EHG, Silvers MA, Jardim GAM, Resende JM, Cavalcanti BC, Bomfim IS, Pessoa C, de Simone CA, Botteselle GV, Braga AL, Nair DK, Namboothiri INN, Boothman DA, da Silva Júnior EN. da Cruz EHG, et al. Among authors: da silva junior en. Eur J Med Chem. 2016 Oct 21;122:1-16. doi: 10.1016/j.ejmech.2016.06.019. Epub 2016 Jun 14. Eur J Med Chem. 2016. PMID: 27341379 Free PMC article.
Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone.
Gontijo TB, de Freitas RP, de Lima GF, de Rezende LC, Pedrosa LF, Silva TL, F Goulart MO, Cavalcanti BC, Pessoa C, Bruno MP, Corrêa JR, Emery FS, da Silva Júnior EN. Gontijo TB, et al. Among authors: da silva junior en, silva tl. Chem Commun (Camb). 2016 Nov 3;52(90):13281-13284. doi: 10.1039/c6cc07054j. Chem Commun (Camb). 2016. PMID: 27775736
On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells.
Gontijo TB, de Freitas RP, Emery FS, Pedrosa LF, Vieira Neto JB, Cavalcanti BC, Pessoa C, King A, de Moliner F, Vendrell M, da Silva Júnior EN. Gontijo TB, et al. Among authors: da silva junior en. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4446-4456. doi: 10.1016/j.bmcl.2017.08.007. Epub 2017 Aug 4. Bioorg Med Chem Lett. 2017. PMID: 28818447 Free article.
Quinonoid compounds via reactions of lawsone and 2-aminonaphthoquinone with α-bromonitroalkenes and nitroallylic acetates: Structural diversity by C-ring modification and cytotoxic evaluation against cancer cells.
Baiju TV, Almeida RG, Sivanandan ST, de Simone CA, Brito LM, Cavalcanti BC, Pessoa C, Namboothiri INN, da Silva Júnior EN. Baiju TV, et al. Among authors: da silva junior en. Eur J Med Chem. 2018 May 10;151:686-704. doi: 10.1016/j.ejmech.2018.03.079. Epub 2018 Apr 5. Eur J Med Chem. 2018. PMID: 29660689
84 results