Cardama G - Search Results

1

Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.

Cabrera M, Echeverria E, Lenicov FR, Cardama G, Gonzalez N, Davio C, Fernández N, Menna PL. Cabrera M, et al. Among authors: cardama g. Oncotarget. 2017 Oct 4;8(58):98509-98523. doi: 10.18632/oncotarget.21533. eCollection 2017 Nov 17. Oncotarget. 2017. PMID: 29228706 Free PMC article.

2

Enhanced cytostatic activity of statins in mouse mammary carcinoma cells overexpressing β2-chimaerin.

Menna PL, Parera RL, Cardama GA, Alonso DF, Gomez DE, Farina HG. Menna PL, et al. Among authors: cardama ga. Mol Med Rep. 2009 Jan-Feb;2(1):97-102. doi: 10.3892/mmr_00000068. Mol Med Rep. 2009. PMID: 21475797

3

Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines.

Cardama GA, Comin MJ, Hornos L, Gonzalez N, Defelipe L, Turjanski AG, Alonso DF, Gomez DE, Menna PL. Cardama GA, et al. Anticancer Agents Med Chem. 2014;14(6):840-51. doi: 10.2174/18715206113136660334. Anticancer Agents Med Chem. 2014. PMID: 24066799 Free PMC article.

4

Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells.

Cardama GA, Gonzalez N, Ciarlantini M, Gandolfi Donadío L, Comin MJ, Alonso DF, Menna PL, Gomez DE. Cardama GA, et al. Onco Targets Ther. 2014 Oct 30;7:2021-33. doi: 10.2147/OTT.S67998. eCollection 2014. Onco Targets Ther. 2014. PMID: 25378937 Free PMC article.

5

Pharmacological inhibition of Rac1-PAK1 axis restores tamoxifen sensitivity in human resistant breast cancer cells.

Gonzalez N, Cardama GA, Comin MJ, Segatori VI, Pifano M, Alonso DF, Gomez DE, Menna PL. Gonzalez N, et al. Among authors: cardama ga. Cell Signal. 2017 Jan;30:154-161. doi: 10.1016/j.cellsig.2016.12.002. Epub 2016 Dec 7. Cell Signal. 2017. PMID: 27939839

6

Rho GTPases as therapeutic targets in cancer (Review).

Cardama GA, Gonzalez N, Maggio J, Menna PL, Gomez DE. Cardama GA, et al. Int J Oncol. 2017 Oct;51(4):1025-1034. doi: 10.3892/ijo.2017.4093. Epub 2017 Aug 9. Int J Oncol. 2017. PMID: 28848995 Free PMC article. Review.

7

[Rho GTPases as molecular targets in cancer. Strategies and therapeutic opportunities].

Maggio J, González N, Cardama GA, Gomez DE. Maggio J, et al. Medicina (B Aires). 2017;77(6):497-504. Medicina (B Aires). 2017. PMID: 29223942 Free article. Review. Spanish.

8

Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics.

Cardama GA, Alonso DF, Gonzalez N, Maggio J, Gomez DE, Rolfo C, Menna PL. Cardama GA, et al. Crit Rev Oncol Hematol. 2018 Apr;124:29-36. doi: 10.1016/j.critrevonc.2018.01.012. Epub 2018 Feb 4. Crit Rev Oncol Hematol. 2018. PMID: 29548483 Review.

9

Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity.

González N, Cardama GA, Chinestrad P, Robles-Valero J, Rodríguez-Fdez S, Lorenzo-Martín LF, Bustelo XR, Lorenzano Menna P, Gomez DE. González N, et al. Among authors: cardama ga. Front Cell Dev Biol. 2020 Apr 15;8:240. doi: 10.3389/fcell.2020.00240. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32351958 Free PMC article.

10

Preclinical Efficacy and Toxicology Evaluation of RAC1 Inhibitor 1A-116 in Human Glioblastoma Models.

Cardama GA, Maggio J, Valdez Capuccino L, Gonzalez N, Matiller V, Ortega HH, Perez GR, Demarco IA, Spitzer E, Gomez DE, Lorenzano Menna P, Alonso DF. Cardama GA, et al. Cancers (Basel). 2022 Sep 30;14(19):4810. doi: 10.3390/cancers14194810. Cancers (Basel). 2022. PMID: 36230732 Free PMC article.

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