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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J Med Chem. 2018 Feb 8;61(3):650-665. doi: 10.1021/acs.jmedchem.7b01375. Epub 2017 Dec 27.
J Med Chem. 2018.
PMID: 29211475
Solution formulation development of a VEGF inhibitor for intravitreal injection.
Marra MT, Khamphavong P, Wisniecki P, Gukasyan HJ, Sueda K.
Marra MT, et al. Among authors: khamphavong p.
AAPS PharmSciTech. 2011 Mar;12(1):362-71. doi: 10.1208/s12249-011-9591-4. Epub 2011 Feb 11.
AAPS PharmSciTech. 2011.
PMID: 21312012
Free PMC article.
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Medium-throughput hydrate screening using the Crystal 16™.
Sistla A, Wu Y, Khamphavong P, Liu J.
Sistla A, et al. Among authors: khamphavong p.
Pharm Dev Technol. 2011 Apr;16(2):102-9. doi: 10.3109/10837450903499366. Epub 2010 Jan 20.
Pharm Dev Technol. 2011.
PMID: 20088649
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Reversible lysine-targeted probes reveal residence time-based kinase selectivity.
Yang T, Cuesta A, Wan X, Craven GB, Hirakawa B, Khamphavong P, May JR, Kath JC, Lapek JD Jr, Niessen S, Burlingame AL, Carelli JD, Taunton J.
Yang T, et al. Among authors: khamphavong p.
Nat Chem Biol. 2022 Sep;18(9):934-941. doi: 10.1038/s41589-022-01019-1. Epub 2022 May 19.
Nat Chem Biol. 2022.
PMID: 35590003
Free PMC article.
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