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Disulfiram as a novel inactivator of Giardia lamblia triosephosphate isomerase with antigiardial potential.
Castillo-Villanueva A, Rufino-González Y, Méndez ST, Torres-Arroyo A, Ponce-Macotela M, Martínez-Gordillo MN, Reyes-Vivas H, Oria-Hernández J. Castillo-Villanueva A, et al. Among authors: reyes vivas h. Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):425-432. doi: 10.1016/j.ijpddr.2017.11.003. Epub 2017 Dec 1. Int J Parasitol Drugs Drug Resist. 2017. PMID: 29197728 Free PMC article.
Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: a study for antiparasitic drug design.
Enríquez-Flores S, Rodríguez-Romero A, Hernández-Alcántara G, Oria-Hernández J, Gutiérrez-Castrellón P, Pérez-Hernández G, de la Mora-de la Mora I, Castillo-Villanueva A, García-Torres I, Méndez ST, Gómez-Manzo S, Torres-Arroyo A, López-Velázquez G, Reyes-Vivas H. Enríquez-Flores S, et al. Proteins. 2011 Sep;79(9):2711-24. doi: 10.1002/prot.23100. Epub 2011 Jul 22. Proteins. 2011. PMID: 21786322
The active (ADHa) and inactive (ADHi) forms of the PQQ-alcohol dehydrogenase from Gluconacetobacter diazotrophicus differ in their respective oligomeric structures and redox state of their corresponding prosthetic groups.
Gómez-Manzo S, González-Valdez AA, Oria-Hernández J, Reyes-Vivas H, Arreguín-Espinosa R, Kroneck PM, Sosa-Torres ME, Escamilla JE. Gómez-Manzo S, et al. FEMS Microbiol Lett. 2012 Mar;328(2):106-13. doi: 10.1111/j.1574-6968.2011.02487.x. Epub 2012 Jan 6. FEMS Microbiol Lett. 2012. PMID: 22188488
Structural and functional perturbation of Giardia lamblia triosephosphate isomerase by modification of a non-catalytic, non-conserved region.
Hernández-Alcántara G, Torres-Larios A, Enríquez-Flores S, García-Torres I, Castillo-Villanueva A, Méndez ST, de la Mora-de la Mora I, Gómez-Manzo S, Torres-Arroyo A, López-Velázquez G, Reyes-Vivas H, Oria-Hernández J. Hernández-Alcántara G, et al. PLoS One. 2013 Jul 22;8(7):e69031. doi: 10.1371/journal.pone.0069031. Print 2013. PLoS One. 2013. PMID: 23894402 Free PMC article.
The E104D mutation increases the susceptibility of human triosephosphate isomerase to proteolysis. Asymmetric cleavage of the two monomers of the homodimeric enzyme.
De La Mora-De La Mora I, Torres-Larios A, Mendoza-Hernández G, Enriquez-Flores S, Castillo-Villanueva A, Mendez ST, Garcia-Torres I, Torres-Arroyo A, Gómez-Manzo S, Marcial-Quino J, Oria-Hernández J, López-Velázquez G, Reyes-Vivas H. De La Mora-De La Mora I, et al. Biochim Biophys Acta. 2013 Dec;1834(12):2702-11. doi: 10.1016/j.bbapap.2013.08.012. Epub 2013 Sep 20. Biochim Biophys Acta. 2013. PMID: 24056040
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