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The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.
Rezende F, Moll F, Walter M, Helfinger V, Hahner F, Janetzko P, Ringel C, Weigert A, Fleming I, Weissmann N, Kuenne C, Looso M, Rieger MA, Nawroth P, Fleming T, Brandes RP, Schröder K. Rezende F, et al. Among authors: nawroth p. Redox Biol. 2018 May;15:12-21. doi: 10.1016/j.redox.2017.11.014. Epub 2017 Nov 22. Redox Biol. 2018. PMID: 29195137 Free PMC article.
Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.
Mendler M, Riedinger C, Schlotterer A, Volk N, Fleming T, Herzig S, Nawroth PP, Morcos M. Mendler M, et al. Among authors: nawroth pp. J Diabetes Complications. 2017 Feb;31(2):304-310. doi: 10.1016/j.jdiacomp.2016.09.014. Epub 2016 Oct 1. J Diabetes Complications. 2017. PMID: 27776915
628 results