Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics.
Vorrink SU, Ullah S, Schmidt S, Nandania J, Velagapudi V, Beck O, Ingelman-Sundberg M, Lauschke VM.
Vorrink SU, et al. Among authors: velagapudi v.
FASEB J. 2017 Jun;31(6):2696-2708. doi: 10.1096/fj.201601375R. Epub 2017 Mar 6.
FASEB J. 2017.
PMID: 28264975
Free PMC article.
We conclude that the 3D spheroid system is metabolically stable and constitutes a suitable model for in vitro studies of long-term drug metabolism and pharmacokinetics.-Vorrink, S. U., Ullah, S., Schmid, S., Nandania, J., Velagapudi, V., Beck, O., Ingelman-Sundberg, …
We conclude that the 3D spheroid system is metabolically stable and constitutes a suitable model for in vitro studies of long-term drug meta …