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Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.
Hatazawa Y, Ono Y, Hirose Y, Kanai S, Fujii NL, Machida S, Nishino I, Shimizu T, Okano M, Kamei Y, Ogawa Y. Hatazawa Y, et al. Among authors: kanai s. FASEB J. 2018 Mar;32(3):1452-1467. doi: 10.1096/fj.201700573R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29146735
This mechanism may play a role in the decreased regeneration capacity during atrophy such as in aged sarcopenia.-Hatazawa, Y., Ono, Y., Hirose, Y., Kanai, S., Fujii, N. L., Machida, S., Nishino, I., Shimizu, T., Okano, M., Kamei, Y., Ogawa, Y. ...
This mechanism may play a role in the decreased regeneration capacity during atrophy such as in aged sarcopenia.-Hatazawa, Y., Ono, Y., Hiro …
The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.
Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y. Yamazaki Y, et al. Among authors: kanai s. Biochem J. 2010 Mar 15;427(1):171-8. doi: 10.1042/BJ20091346. Biochem J. 2010. PMID: 20088826
Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRγ in skeletal muscle.
Sugita S, Kamei Y, Akaike F, Suganami T, Kanai S, Hattori M, Manabe Y, Fujii N, Takai-Igarashi T, Tadaishi M, Oka J, Aburatani H, Yamada T, Katagiri H, Kakehi S, Tamura Y, Kubo H, Nishida K, Miura S, Ezaki O, Ogawa Y. Sugita S, et al. Among authors: kanai s. PLoS One. 2011;6(5):e20467. doi: 10.1371/journal.pone.0020467. Epub 2011 May 31. PLoS One. 2011. PMID: 21655215 Free PMC article.
FOXO1 activates glutamine synthetase gene in mouse skeletal muscles through a region downstream of 3'-UTR: possible contribution to ammonia detoxification.
Kamei Y, Hattori M, Hatazawa Y, Kasahara T, Kanou M, Kanai S, Yuan X, Suganami T, Lamers WH, Kitamura T, Ogawa Y. Kamei Y, et al. Among authors: kanai s. Am J Physiol Endocrinol Metab. 2014 Sep 15;307(6):E485-93. doi: 10.1152/ajpendo.00177.2014. Epub 2014 Jul 29. Am J Physiol Endocrinol Metab. 2014. PMID: 25074987 Free article.
ATM Regulates Adipocyte Differentiation and Contributes to Glucose Homeostasis.
Takagi M, Uno H, Nishi R, Sugimoto M, Hasegawa S, Piao J, Ihara N, Kanai S, Kakei S, Tamura Y, Suganami T, Kamei Y, Shimizu T, Yasuda A, Ogawa Y, Mizutani S. Takagi M, et al. Among authors: kanai s. Cell Rep. 2015 Feb 17;10(6):957-967. doi: 10.1016/j.celrep.2015.01.027. Epub 2015 Feb 12. Cell Rep. 2015. PMID: 25683718 Free article.
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