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PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes.
Ben Nasr M, Tezza S, D'Addio F, Mameli C, Usuelli V, Maestroni A, Corradi D, Belletti S, Albarello L, Becchi G, Fadini GP, Schuetz C, Markmann J, Wasserfall C, Zon L, Zuccotti GV, Fiorina P. Ben Nasr M, et al. Among authors: markmann j. Sci Transl Med. 2017 Nov 15;9(416):eaam7543. doi: 10.1126/scitranslmed.aam7543. Sci Transl Med. 2017. PMID: 29141886 Free PMC article.
A novel clinically relevant strategy to abrogate autoimmunity and regulate alloimmunity in NOD mice.
Vergani A, D'Addio F, Jurewicz M, Petrelli A, Watanabe T, Liu K, Law K, Schuetz C, Carvello M, Orsenigo E, Deng S, Rodig SJ, Ansari JM, Staudacher C, Abdi R, Williams J, Markmann J, Atkinson M, Sayegh MH, Fiorina P. Vergani A, et al. Among authors: markmann j. Diabetes. 2010 Sep;59(9):2253-64. doi: 10.2337/db09-1264. Diabetes. 2010. PMID: 20805386 Free PMC article.
IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response.
Petrelli A, Carvello M, Vergani A, Lee KM, Tezza S, Du M, Kleffel S, Chengwen L, Mfarrej BG, Hwu P, Secchi A, Leonard WJ, Young D, Sayegh MH, Markmann JF, Zajac AJ, Fiorina P. Petrelli A, et al. Among authors: markmann jf. Diabetes. 2011 Dec;60(12):3223-34. doi: 10.2337/db11-0880. Epub 2011 Oct 19. Diabetes. 2011. PMID: 22013017 Free PMC article.
B-cell depletion improves islet allograft survival with anti-CD45RB.
Lee KM, Yeh H, Zhao G, Wei L, O'Connor M, Stott RT, Soohoo J, Dunussi K, Fiorina P, Deng S, Markmann JF, Kim JI. Lee KM, et al. Among authors: markmann jf. Cell Transplant. 2014 Jan;23(1):51-8. doi: 10.3727/096368912X658962. Epub 2012 Nov 27. Cell Transplant. 2014. PMID: 23192154 Free PMC article.
394 results