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Evaluation of the efficacy and safety of β-d-mannuronic acid in patients with ankylosing spondylitis: A 12-week randomized, placebo-controlled, phase I/II clinical trial.
Fattahi MJ, Jamshidi AR, Mahmoudi M, Vojdanian M, Yekaninejad MS, Jafarnezhad-Ansariha F, Ahmadi H, Rehm BHA, Matsuo H, Cuzzocrea S, Hosseini M, Hashemi SN, Aghazadeh Z, Mirshafiey A. Fattahi MJ, et al. Int Immunopharmacol. 2018 Jan;54:112-117. doi: 10.1016/j.intimp.2017.11.003. Epub 2017 Nov 8. Int Immunopharmacol. 2018. PMID: 29127910 Clinical Trial.
The effects of β-D-mannuronic acid (M2000), as a novel NSAID, on COX1 and COX2 activities and gene expression in ankylosing spondylitis patients and the murine monocyte/macrophage, J774 cell line.
Jafarnezhad-Ansariha F, Yekaninejad MS, Jamshidi AR, Mansouri R, Vojdanian M, Mahmoudi M, Fattahi MJ, Hashemi SN, Rehm BHA, Matsuo H, Esposito E, Cuzzocrea S, Mirshafiey A. Jafarnezhad-Ansariha F, et al. Inflammopharmacology. 2018 Apr;26(2):375-384. doi: 10.1007/s10787-017-0386-4. Epub 2017 Aug 17. Inflammopharmacology. 2018. PMID: 28819782 Clinical Trial.
The Anti-tumoral Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID on Treg Cells Frequency and MMP-2, MMP-9, CCL22 and TGFβ1 Gene Expression in Pre-surgical Breast Cancer Patients.
Kashefi S, Ahmadi H, Omranipour R, Mahmoodzadeh H, Jafarnezhad-Ansariha F, Tofighi Zavareh F, Mirshafiey A. Kashefi S, et al. Among authors: jafarnezhad ansariha f. Iran J Allergy Asthma Immunol. 2019 Feb;18(1):80-90. Iran J Allergy Asthma Immunol. 2019. PMID: 30848576 Free article. Clinical Trial.
Effects of guluronic acid, as a new NSAID with immunomodulatory properties on IL-17, RORγt, IL-4 and GATA-3 gene expression in rheumatoid arthritis patients.
Khadem Azarian S, Jafarnezhad-Ansariha F, Nazeri S, Azizi G, Aghazadeh Z, Hosseinzadeh E, Mirshafiey A. Khadem Azarian S, et al. Among authors: jafarnezhad ansariha f. Immunopharmacol Immunotoxicol. 2020 Feb;42(1):22-27. doi: 10.1080/08923973.2019.1702053. Epub 2019 Dec 19. Immunopharmacol Immunotoxicol. 2020. PMID: 31856612 Clinical Trial.
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