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Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes.
Law BA, Liao X, Moore KS, Southard A, Roddy P, Ji R, Szulc Z, Bielawska A, Schulze PC, Cowart LA. Law BA, et al. Among authors: liao x. FASEB J. 2018 Mar;32(3):1403-1416. doi: 10.1096/fj.201700300R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29127192 Free PMC article.
Our data reveal a novel lipotoxic pathway through CerS2.-Law, B. A., Liao, X., Moore, K. S., Southard, A., Roddy, P., Ji, R., Szulc, Z., Bielawska, A., Schulze, P. ...
Our data reveal a novel lipotoxic pathway through CerS2.-Law, B. A., Liao, X., Moore, K. S., Southard, A., Roddy, P., Ji, R., …
Increased de novo ceramide synthesis and accumulation in failing myocardium.
Ji R, Akashi H, Drosatos K, Liao X, Jiang H, Kennel PJ, Brunjes DL, Castillero E, Zhang X, Deng LY, Homma S, George IJ, Takayama H, Naka Y, Goldberg IJ, Schulze PC. Ji R, et al. Among authors: liao x. JCI Insight. 2017 May 4;2(9):e82922. doi: 10.1172/jci.insight.82922. eCollection 2017 May 4. JCI Insight. 2017. PMID: 28469091 Free PMC article.
MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation.
Zhang X, Ji R, Liao X, Castillero E, Kennel PJ, Brunjes DL, Franz M, Möbius-Winkler S, Drosatos K, George I, Chen EI, Colombo PC, Schulze PC. Zhang X, et al. Among authors: liao x. Circulation. 2018 May 8;137(19):2052-2067. doi: 10.1161/CIRCULATIONAHA.117.030486. Epub 2018 Jan 12. Circulation. 2018. PMID: 29330215 Free PMC article.
Impairment of Myocardial Glutamine Homeostasis Induced By Suppression of the Amino Acid Carrier SLC1A5 in Failing Myocardium.
Kennel PJ, Liao X, Saha A, Ji R, Zhang X, Castillero E, Brunjes D, Takayama H, Naka Y, Thomas T, George I, Mancini D, Schulze PC. Kennel PJ, et al. Among authors: liao x. Circ Heart Fail. 2019 Dec;12(12):e006336. doi: 10.1161/CIRCHEARTFAILURE.119.006336. Epub 2019 Dec 12. Circ Heart Fail. 2019. PMID: 31826641 No abstract available.
Activin type II receptor ligand signaling inhibition after experimental ischemic heart failure attenuates cardiac remodeling and prevents fibrosis.
Castillero E, Akashi H, Najjar M, Ji R, Brandstetter LM, Wang C, Liao X, Zhang X, Sperry A, Gailes M, Guaman K, Recht A, Schlosberg I, Sweeney HL, Ali ZA, Homma S, Colombo PC, Ferrari G, Schulze PC, George I. Castillero E, et al. Among authors: liao x. Am J Physiol Heart Circ Physiol. 2020 Feb 1;318(2):H378-H390. doi: 10.1152/ajpheart.00302.2019. Epub 2019 Dec 30. Am J Physiol Heart Circ Physiol. 2020. PMID: 31886717 Free PMC article.
Increased de novo ceramide synthesis and accumulation in failing myocardium.
Ji R, Akashi H, Drosatos K, Liao X, Jiang H, Kennel PJ, Brunjes DL, Castillero E, Zhang X, Deng LY, Homma S, George IJ, Takayama H, Naka Y, Goldberg IJ, Schulze PC. Ji R, et al. Among authors: liao x. JCI Insight. 2017 Jul 20;2(14):e96203. doi: 10.1172/jci.insight.96203. eCollection 2017 Jul 20. JCI Insight. 2017. PMID: 28724803 Free PMC article. No abstract available.
Adrenergic CaV1.2 Activation via Rad Phosphorylation Converges at α1C I-II Loop.
Papa A, Kushner J, Hennessey JA, Katchman AN, Zakharov SI, Chen BX, Yang L, Lu R, Leong S, Diaz J, Liu G, Roybal D, Liao X, Del Rivero Morfin PJ, Colecraft HM, Pitt GS, Clarke O, Topkara V, Ben-Johny M, Marx SO. Papa A, et al. Among authors: liao x. Circ Res. 2021 Jan 8;128(1):76-88. doi: 10.1161/CIRCRESAHA.120.317839. Epub 2020 Oct 22. Circ Res. 2021. PMID: 33086983 Free PMC article.
Stereotactic radiotherapy vs whole brain radiation therapy in EGFR mutated NSCLC: Results & reflections from the prematurely closed phase III HYBRID trial.
Zeng M, Verma V, Chen X, Li S, Sun Y, Liu G, Tian X, Zhang D, Li J, Liu Y, Liao X, Liu Y, Wang L, Wang X, Shi H, Li B, Xue B, Luo X. Zeng M, et al. Among authors: liao x. Radiother Oncol. 2024 May 25:110334. doi: 10.1016/j.radonc.2024.110334. Online ahead of print. Radiother Oncol. 2024. PMID: 38801945
7,092 results