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Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes.
Law BA, Liao X, Moore KS, Southard A, Roddy P, Ji R, Szulc Z, Bielawska A, Schulze PC, Cowart LA. Law BA, et al. Among authors: bielawska a. FASEB J. 2018 Mar;32(3):1403-1416. doi: 10.1096/fj.201700300R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29127192 Free PMC article.
Our data reveal a novel lipotoxic pathway through CerS2.-Law, B. A., Liao, X., Moore, K. S., Southard, A., Roddy, P., Ji, R., Szulc, Z., Bielawska, A., Schulze, P. C., Cowart, L. ...
Our data reveal a novel lipotoxic pathway through CerS2.-Law, B. A., Liao, X., Moore, K. S., Southard, A., Roddy, P., J …
Molecular cloning and characterization of a human mitochondrial ceramidase.
El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA. El Bawab S, et al. Among authors: bielawska a. J Biol Chem. 2000 Jul 14;275(28):21508-13. doi: 10.1074/jbc.M002522200. J Biol Chem. 2000. PMID: 10781606 Free article.
We have recently purified a rat brain membrane-bound nonlysosomal ceramidase (El Bawab, S., Bielawska, A., and Y. ...Analysis of the protein sequence revealed the presence at the N terminus of a signal peptide followed by a putative myristoylati …
We have recently purified a rat brain membrane-bound nonlysosomal ceramidase (El Bawab, S., Bielawska, A., and Y. ...An …
Radiolabeling of the sphingolipid backbone.
Bielawska A, Hannum YA, Szulc Z. Bielawska A, et al. Methods Enzymol. 2000;311:480-98. doi: 10.1016/s0076-6879(00)11101-2. Methods Enzymol. 2000. PMID: 10563345 No abstract available.
Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide.
Mao C, Xu R, Bielawska A, Szulc ZM, Obeid LM. Mao C, et al. Among authors: bielawska a. J Biol Chem. 2000 Oct 6;275(40):31369-78. doi: 10.1074/jbc.M003683200. J Biol Chem. 2000. PMID: 10900202 Free article.
In a previous study, we reported that the Saccharomyces cerevisiae gene YPC1 encodes an alkaline ceramidase with a dual activity, catalyzing both hydrolysis and synthesis of yeast ceramide (Mao, C., Xu, R., Bielawska, A., and Obeid, L. ...Biol. Chem. 2 …
In a previous study, we reported that the Saccharomyces cerevisiae gene YPC1 encodes an alkaline ceramidase with a dual activi …
Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide.
Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM. Mao C, et al. Among authors: bielawska a. J Biol Chem. 2001 Jul 13;276(28):26577-88. doi: 10.1074/jbc.M102818200. Epub 2001 May 16. J Biol Chem. 2001. PMID: 11356846 Free article.
Based on sequence homology to the yeast alkaline ceramidases YPC1p (Mao, C., Xu, R., Bielawska, A., and Obeid, L. M. (2000) J. Biol. Chem. 275, 6876--6884) and YDC1p (Mao, C., Xu, R., Bielawska, A., Szulc, Z. ...Biol Chem. 275, 31369--31378), we report …
Based on sequence homology to the yeast alkaline ceramidases YPC1p (Mao, C., Xu, R., Bielawska, A., and Obeid, L. M. (2000) J. …
Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice.
Dahm F, Bielawska A, Nocito A, Georgiev P, Szulc ZM, Bielawski J, Jochum W, Dindo D, Hannun YA, Clavien PA. Dahm F, et al. Among authors: bielawska a. Br J Cancer. 2008 Jan 15;98(1):98-105. doi: 10.1038/sj.bjc.6604099. Epub 2007 Nov 20. Br J Cancer. 2008. PMID: 18026195 Free PMC article.
Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.
Bielawska A, Linardic CM, Hannun YA. Bielawska A, et al. J Biol Chem. 1992 Sep 15;267(26):18493-7. J Biol Chem. 1992. PMID: 1526986 Free article.
Ceramide is a postulated intracellular modulator of cell growth and differentiation (Okazaki, T., Bielawska, A., Bell, R.M., and Hannun, Y. ...These compounds share with ceramide a similar polar headgroup that allows the investigation of the roles of t …
Ceramide is a postulated intracellular modulator of cell growth and differentiation (Okazaki, T., Bielawska, A., Bell, …
283 results