Cons BD - Search Results

1

Fragment-based drug discovery and its application to challenging drug targets.

Price AJ, Howard S, Cons BD. Price AJ, et al. Among authors: cons bd. Essays Biochem. 2017 Nov 8;61(5):475-484. doi: 10.1042/EBC20170029. Print 2017 Nov 8. Essays Biochem. 2017. PMID: 29118094 Review.

2

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.

Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscombe E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor SJ, Hearn K, Hobson S, Holvey RS, Howard S, Jennings CE, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, St Denis JD, Tamanini E, Thomas H, Thompson NT, Vinković M, Wedge SR, Williams PA, Wilsher NE, Zhang B, Zhao Y. Chessari G, et al. J Med Chem. 2021 Apr 8;64(7):4071-4088. doi: 10.1021/acs.jmedchem.0c02188. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33761253

3

Electrostatic Complementarity in Structure-Based Drug Design.

Cons BD, Twigg DG, Kumar R, Chessari G. Cons BD, et al. J Med Chem. 2022 Jun 9;65(11):7476-7488. doi: 10.1021/acs.jmedchem.2c00164. Epub 2022 May 5. J Med Chem. 2022. PMID: 35512344 Review.

4

X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor.

St Denis JD, Chessari G, Cleasby A, Cons BD, Cowan S, Dalton SE, East C, Murray CW, O'Reilly M, Peakman T, Rapti M, Stow JL. St Denis JD, et al. Among authors: cons bd. J Med Chem. 2022 Sep 22;65(18):12319-12333. doi: 10.1021/acs.jmedchem.2c01044. Epub 2022 Sep 13. J Med Chem. 2022. PMID: 36101934

5

Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.

Tamanini E, Miyamura S, Buck IM, Cons BD, Dawson L, East C, Futamura T, Goto S, Griffiths-Jones C, Hashimoto T, Heightman TD, Ishikawa S, Ito H, Kaneko Y, Kawato T, Kondo K, Kurihara N, McCarthy JM, Mori Y, Nagase T, Nakaishi Y, Reeks J, Sato A, Schöpf P, Tai K, Tamai T, Tisi D, Woolford AJ. Tamanini E, et al. Among authors: cons bd. ACS Med Chem Lett. 2022 Sep 6;13(10):1591-1597. doi: 10.1021/acsmedchemlett.2c00272. eCollection 2022 Oct 13. ACS Med Chem Lett. 2022. PMID: 36262388 Free PMC article.

6

Enabling synthesis in fragment-based drug discovery (FBDD): microscale high-throughput optimisation of the medicinal chemist's toolbox reactions.

Townley C, Branduardi D, Chessari G, Cons BD, Griffiths-Jones C, Hall RJ, Johnson CN, Ochi Y, Whibley S, Grainger R. Townley C, et al. Among authors: cons bd. RSC Med Chem. 2023 Nov 24;14(12):2699-2713. doi: 10.1039/d3md00495c. eCollection 2023 Dec 13. RSC Med Chem. 2023. PMID: 38107176

7

Alkene 1,3-Difluorination via Transient Oxonium Intermediates.

Dean AC, Randle EH, Lacey AJD, Marczak Giorio GA, Doobary S, Cons BD, Lennox A. Dean AC, et al. Among authors: cons bd. Angew Chem Int Ed Engl. 2024 May 2:e202404666. doi: 10.1002/anie.202404666. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 38695434

8

Total synthesis of (-)-blepharocalyxin D and analogues.

Cons BD, Bunt AJ, Bailey CD, Willis CL. Cons BD, et al. Org Lett. 2013 Apr 19;15(8):2046-9. doi: 10.1021/ol400736w. Epub 2013 Apr 5. Org Lett. 2013. PMID: 23560679

9

Bicyclic oxygen heterocycles from γ,δ-unsaturated alcohols: synthetic targets inspired by blepharocalyxin D.

Bunt AJ, Bailey CD, Cons BD, Edwards SJ, Elsworth JD, Pheko T, Willis CL. Bunt AJ, et al. Among authors: cons bd. Angew Chem Int Ed Engl. 2012 Apr 16;51(16):3901-4. doi: 10.1002/anie.201108315. Epub 2012 Mar 5. Angew Chem Int Ed Engl. 2012. PMID: 22392806

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

9 results

Search Page