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Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.
Honorat JA, Nakatsuji Y, Shimizu M, Kinoshita M, Sumi-Akamaru H, Sasaki T, Takata K, Koda T, Namba A, Yamashita K, Sanda E, Sakaguchi M, Kumanogoh A, Shirakura T, Tamura M, Sakoda S, Mochizuki H, Okuno T. Honorat JA, et al. Among authors: yamashita k. PLoS One. 2017 Nov 6;12(11):e0187215. doi: 10.1371/journal.pone.0187215. eCollection 2017. PLoS One. 2017. PMID: 29107957 Free PMC article.
Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.
Hosokawa T, Kimura T, Nada S, Okuno T, Ito D, Kang S, Nojima S, Yamashita K, Nakatani T, Hayama Y, Kato Y, Kinehara Y, Nishide M, Mikami N, Koyama S, Takamatsu H, Okuzaki D, Ohkura N, Sakaguchi S, Okada M, Kumanogoh A. Hosokawa T, et al. Among authors: yamashita k. J Immunol. 2017 Sep 15;199(6):2008-2019. doi: 10.4049/jimmunol.1700157. Epub 2017 Aug 2. J Immunol. 2017. PMID: 28768723
Beneficial effects of fingolimod in MS patients with high serum Sema4A levels.
Koda T, Namba A, Nakatsuji Y, Niino M, Miyazaki Y, Sugimoto T, Kinoshita M, Takata K, Yamashita K, Shimizu M, Fukazawa T, Kumanogoh A, Mochizuki H, Okuno T. Koda T, et al. Among authors: yamashita k. PLoS One. 2018 Mar 8;13(3):e0193986. doi: 10.1371/journal.pone.0193986. eCollection 2018. PLoS One. 2018. PMID: 29518148 Free PMC article.
Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder.
Yamashita K, Kinoshita M, Miyamoto K, Namba A, Shimizu M, Koda T, Sugimoto T, Mori Y, Yoshioka Y, Nakatsuji Y, Kumanogoh A, Kusunoki S, Mochizuki H, Okuno T. Yamashita K, et al. J Neuroinflammation. 2018 Apr 27;15(1):125. doi: 10.1186/s12974-018-1162-0. J Neuroinflammation. 2018. PMID: 29703264 Free PMC article.
Single injection of sustained-release prostacyclin analog ONO-1301-MS ameliorates hypoxic toxicity in the murine model of amyotrophic lateral sclerosis.
Tada S, Okuno T, Shimizu M, Sakai Y, Sumi-Akamaru H, Kinoshita M, Yamashita K, Sanda E, Choong CJ, Namba A, Sasaki T, Koda T, Takata K, Miyagawa S, Sawa Y, Nakatsuji Y, Mochizuki H. Tada S, et al. Among authors: yamashita k. Sci Rep. 2019 Mar 27;9(1):5252. doi: 10.1038/s41598-019-41771-4. Sci Rep. 2019. PMID: 30918303 Free PMC article.
Sema4A is implicated in the acceleration of Th17 cell-mediated neuroinflammation in the effector phase.
Koda T, Namba A, Kinoshita M, Nakatsuji Y, Sugimoto T, Sakakibara K, Tada S, Shimizu M, Yamashita K, Takata K, Ishikura T, Murata S, Beppu S, Kumanogoh A, Mochizuki H, Okuno T. Koda T, et al. Among authors: yamashita k. J Neuroinflammation. 2020 Mar 13;17(1):82. doi: 10.1186/s12974-020-01757-w. J Neuroinflammation. 2020. PMID: 32169103 Free PMC article.
Mitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation.
Shimizu M, Okuno T, Kinoshita M, Sumi H, Fujimura H, Yamashita K, Sugimoto T, Sakakibara S, Sakakibara K, Koda T, Tada S, Ishikura T, Murata H, Beppu S, Shiraishi N, Sugiyama Y, Nakatsuji Y, Kumanogoh A, Mochizuki H. Shimizu M, et al. Among authors: yamashita k. Sci Rep. 2020 Aug 6;10(1):13274. doi: 10.1038/s41598-020-70203-x. Sci Rep. 2020. PMID: 32764561 Free PMC article.
Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats.
Ishikura T, Kinoshita M, Shimizu M, Yasumizu Y, Motooka D, Okuzaki D, Yamashita K, Murata H, Beppu S, Koda T, Tada S, Shiraishi N, Sugiyama Y, Miyamoto K, Kusunoki S, Sugimoto T, Kumanogoh A, Okuno T, Mochizuki H. Ishikura T, et al. Among authors: yamashita k. J Neuroinflammation. 2021 Aug 21;18(1):181. doi: 10.1186/s12974-021-02232-w. J Neuroinflammation. 2021. PMID: 34419102 Free PMC article.
Food additive succinate exacerbates experimental autoimmune encephalomyelitis accompanied by increased IL-1β production.
Sugiyama Y, Takata K, Kinoshita M, Motooka D, Shiraishi N, Kihara K, Murata H, Beppu S, Koda T, Yamashita K, Namba A, Fujimoto K, Kumanogoh A, Okuno T, Mochizuki H. Sugiyama Y, et al. Among authors: yamashita k. Biochem Biophys Res Commun. 2023 May 14;656:97-103. doi: 10.1016/j.bbrc.2023.03.041. Epub 2023 Mar 16. Biochem Biophys Res Commun. 2023. PMID: 36958260 No abstract available.
5,480 results