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Cytotoxic and cytostatic effects of digitoxigenin monodigitoxoside (DGX) in human lung cancer cells and its link to Na,K-ATPase.
Schneider NFZ, Persich L, Rocha SC, Ramos ACP, Cortes VF, Silva IT, Munkert J, Pádua RM, Kreis W, Taranto AG, Barbosa LA, Braga FC, Simões CMO. Schneider NFZ, et al. Among authors: taranto ag. Biomed Pharmacother. 2018 Jan;97:684-696. doi: 10.1016/j.biopha.2017.10.128. Epub 2017 Nov 6. Biomed Pharmacother. 2018. PMID: 29101813
21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions.
Rocha SC, Pessoa MT, Neves LD, Alves SL, Silva LM, Santos HL, Oliveira SM, Taranto AG, Comar M, Gomes IV, Santos FV, Paixão N, Quintas LE, Noël F, Pereira AF, Tessis AC, Gomes NL, Moreira OC, Rincon-Heredia R, Varotti FP, Blanco G, Villar JA, Contreras RG, Barbosa LA. Rocha SC, et al. Among authors: taranto ag. PLoS One. 2014 Oct 7;9(10):e108776. doi: 10.1371/journal.pone.0108776. eCollection 2014. PLoS One. 2014. PMID: 25290152 Free PMC article.
γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect.
Alves SLG, Paixão N, Ferreira LGR, Santos FRS, Neves LDR, Oliveira GC, Cortes VF, Salomé KS, Barison A, Santos FV, Cenzi G, Varotti FP, Oliveira SMF, Taranto AG, Comar M, Silva LM, Noël F, Quintas LEM, Barbosa LA, Villar JAFP. Alves SLG, et al. Among authors: taranto ag. Bioorg Med Chem. 2015 Aug 1;23(15):4397-4404. doi: 10.1016/j.bmc.2015.06.028. Epub 2015 Jun 17. Bioorg Med Chem. 2015. PMID: 26122772 Free article.
Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation.
Schneider NFZ, Silva IT, Persich L, de Carvalho A, Rocha SC, Marostica L, Ramos ACP, Taranto AG, Pádua RM, Kreis W, Barbosa LA, Braga FC, Simões CMO. Schneider NFZ, et al. Among authors: taranto ag. Mol Cell Biochem. 2017 Apr;428(1-2):23-39. doi: 10.1007/s11010-016-2914-8. Epub 2017 Feb 7. Mol Cell Biochem. 2017. PMID: 28176244
Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na+/K+-ATPase inhibition.
Silva IT, Munkert J, Nolte E, Schneider NFZ, Rocha SC, Ramos ACP, Kreis W, Braga FC, de Pádua RM, Taranto AG, Cortes V, Barbosa LA, Wach S, Taubert H, Simões CMO. Silva IT, et al. Among authors: taranto ag. Biomed Pharmacother. 2018 Nov;107:464-474. doi: 10.1016/j.biopha.2018.08.028. Epub 2018 Aug 11. Biomed Pharmacother. 2018. PMID: 30107342
Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca²⁺-ATPase PfATP6.
Guimarães DS, Fonseca AL, Batista R, Comar Junior M, Oliveira AB, Taranto AG, Varotti Fde P. Guimarães DS, et al. Among authors: taranto ag. Mem Inst Oswaldo Cruz. 2015 Apr;110(2):255-8. doi: 10.1590/0074-02760140415. Mem Inst Oswaldo Cruz. 2015. PMID: 25946251 Free PMC article.
56 results