Maclean KN - Search Results

1

Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.

Maclean KN, Jiang H, Aivazidis S, Kim E, Shearn CT, Harris PS, Petersen DR, Allen RH, Stabler SP, Roede JR. Maclean KN, et al. FASEB J. 2018 Mar;32(3):1265-1280. doi: 10.1096/fj.201700586R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29101223

2

A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.

Maclean KN, Sikora J, Kožich V, Jiang H, Greiner LS, Kraus E, Krijt J, Overdier KH, Collard R, Brodsky GL, Meltesen L, Crnic LS, Allen RH, Stabler SP, Elleder M, Rozen R, Patterson D, Kraus JP. Maclean KN, et al. Mol Genet Metab. 2010 Oct-Nov;101(2-3):153-62. doi: 10.1016/j.ymgme.2010.06.010. Epub 2010 Jun 23. Mol Genet Metab. 2010. PMID: 20638879 Free PMC article.

3

Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.

Maclean KN, Jiang H, Greiner LS, Allen RH, Stabler SP. Maclean KN, et al. Mol Genet Metab. 2012 Mar;105(3):395-403. doi: 10.1016/j.ymgme.2011.11.190. Epub 2011 Dec 2. Mol Genet Metab. 2012. PMID: 22192524

4

Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes.

Jiang H, Stabler SP, Allen RH, Maclean KN. Jiang H, et al. Among authors: maclean kn. Mol Genet Metab. 2012 Sep;107(1-2):55-65. doi: 10.1016/j.ymgme.2012.04.025. Epub 2012 May 5. Mol Genet Metab. 2012. PMID: 22633282

5

Altered hepatic sulfur metabolism in cystathionine β-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways.

Jiang H, Stabler SP, Allen RH, Abman SH, Maclean KN. Jiang H, et al. Among authors: maclean kn. FASEB J. 2014 Sep;28(9):4044-54. doi: 10.1096/fj.14-253633. Epub 2014 Jun 2. FASEB J. 2014. PMID: 24891521 Free PMC article.

6

Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria.

Jacobs RL, Jiang H, Kennelly JP, Orlicky DJ, Allen RH, Stabler SP, Maclean KN. Jacobs RL, et al. Among authors: maclean kn. Mol Genet Metab. 2017 Apr;120(4):325-336. doi: 10.1016/j.ymgme.2017.02.010. Epub 2017 Mar 2. Mol Genet Metab. 2017. PMID: 28291718

7

Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria.

Maclean KN, Jiang H, Phinney WN, Keating AK, Hurt KJ, Stabler SP. Maclean KN, et al. FASEB J. 2019 May;33(5):6339-6353. doi: 10.1096/fj.201802069RR. Epub 2019 Feb 15. FASEB J. 2019. PMID: 30768359

8

Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.

Maclean KN, Jiang H, Phinney WN, Mclagan BM, Roede JR, Stabler SP. Maclean KN, et al. Mol Genet Metab. 2021 Feb;132(2):128-138. doi: 10.1016/j.ymgme.2021.01.003. Epub 2021 Jan 11. Mol Genet Metab. 2021. PMID: 33483253

9

Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment.

Maclean KN, Sikora J, Kožich V, Jiang H, Greiner LS, Kraus E, Krijt J, Crnic LS, Allen RH, Stabler SP, Elleder M, Kraus JP. Maclean KN, et al. Mol Genet Metab. 2010 Oct-Nov;101(2-3):163-71. doi: 10.1016/j.ymgme.2010.06.007. Epub 2010 Jun 22. Mol Genet Metab. 2010. PMID: 20638882 Free PMC article.

10

Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria.

Keating AK, Freehauf C, Jiang H, Brodsky GL, Stabler SP, Allen RH, Graham DK, Thomas JA, Van Hove JL, Maclean KN. Keating AK, et al. Among authors: maclean kn. Mol Genet Metab. 2011 Aug;103(4):330-7. doi: 10.1016/j.ymgme.2011.04.012. Epub 2011 May 5. Mol Genet Metab. 2011. PMID: 21601502 Free PMC article.

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