Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.
Maclean KN, Jiang H, Aivazidis S, Kim E, Shearn CT, Harris PS, Petersen DR, Allen RH, Stabler SP, Roede JR.
Maclean KN, et al. Among authors: jiang h.
FASEB J. 2018 Mar;32(3):1265-1280. doi: 10.1096/fj.201700586R. Epub 2018 Jan 3.
FASEB J. 2018.
PMID: 29101223
Collectively, our data indicate that the perturbation of the gamma-glutamyl cycle could contribute to multiple sequelae in HCU and that taurine has significant therapeutic potential for both HCU and other diseases for which GSH depletion is a critical pathogenic factor.-Maclean, …
Collectively, our data indicate that the perturbation of the gamma-glutamyl cycle could contribute to multiple sequelae in HCU and that taur …