Newcombe J - Search Results

1

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models.

Tyzack GE, Hall CE, Sibley CR, Cymes T, Forostyak S, Carlino G, Meyer IF, Schiavo G, Zhang SC, Gibbons GM, Newcombe J, Patani R, Lakatos A. Tyzack GE, et al. Among authors: newcombe j. Nat Commun. 2017 Oct 27;8(1):1164. doi: 10.1038/s41467-017-01283-z. Nat Commun. 2017. PMID: 29079839 Free PMC article.

2

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS.

Luisier R, Tyzack GE, Hall CE, Mitchell JS, Devine H, Taha DM, Malik B, Meyer I, Greensmith L, Newcombe J, Ule J, Luscombe NM, Patani R. Luisier R, et al. Among authors: newcombe j. Nat Commun. 2018 May 22;9(1):2010. doi: 10.1038/s41467-018-04373-8. Nat Commun. 2018. PMID: 29789581 Free PMC article.

3

Automated and unbiased discrimination of ALS from control tissue at single cell resolution.

Hagemann C, Tyzack GE, Taha DM, Devine H, Greensmith L, Newcombe J, Patani R, Serio A, Luisier R. Hagemann C, et al. Among authors: newcombe j. Brain Pathol. 2021 Jul;31(4):e12937. doi: 10.1111/bpa.12937. Epub 2021 Feb 11. Brain Pathol. 2021. PMID: 33576079 Free PMC article.

4

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.

Tyzack GE, Luisier R, Taha DM, Neeves J, Modic M, Mitchell JS, Meyer I, Greensmith L, Newcombe J, Ule J, Luscombe NM, Patani R. Tyzack GE, et al. Among authors: newcombe j. Brain. 2019 Sep 1;142(9):2572-2580. doi: 10.1093/brain/awz217. Brain. 2019. PMID: 31368485 Free PMC article.

5

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis.

Smethurst P, Risse E, Tyzack GE, Mitchell JS, Taha DM, Chen YR, Newcombe J, Collinge J, Sidle K, Patani R. Smethurst P, et al. Among authors: newcombe j. Brain. 2020 Feb 1;143(2):430-440. doi: 10.1093/brain/awz419. Brain. 2020. PMID: 32040555 Free PMC article.

6

Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS.

Tyzack GE, Manferrari G, Newcombe J, Luscombe NM, Luisier R, Patani R. Tyzack GE, et al. Among authors: newcombe j. Brain. 2020 Aug 1;143(8):e66. doi: 10.1093/brain/awaa205. Brain. 2020. PMID: 32844195 Free PMC article. No abstract available.

7

In vitro prion-like behaviour of TDP-43 in ALS.

Smethurst P, Newcombe J, Troakes C, Simone R, Chen YR, Patani R, Sidle K. Smethurst P, et al. Among authors: newcombe j. Neurobiol Dis. 2016 Dec;96:236-247. doi: 10.1016/j.nbd.2016.08.007. Epub 2016 Aug 30. Neurobiol Dis. 2016. PMID: 27590623 Free PMC article.

8

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.

Brown AL, Wilkins OG, Keuss MJ, Hill SE, Zanovello M, Lee WC, Bampton A, Lee FCY, Masino L, Qi YA, Bryce-Smith S, Gatt A, Hallegger M, Fagegaltier D, Phatnani H; NYGC ALS Consortium; Newcombe J, Gustavsson EK, Seddighi S, Reyes JF, Coon SL, Ramos D, Schiavo G, Fisher EMC, Raj T, Secrier M, Lashley T, Ule J, Buratti E, Humphrey J, Ward ME, Fratta P. Brown AL, et al. Among authors: newcombe j. Nature. 2022 Mar;603(7899):131-137. doi: 10.1038/s41586-022-04436-3. Epub 2022 Feb 23. Nature. 2022. PMID: 35197628 Free PMC article.

9

Production of IL-27 in multiple sclerosis lesions by astrocytes and myeloid cells: Modulation of local immune responses.

Sénécal V, Deblois G, Beauseigle D, Schneider R, Brandenburg J, Newcombe J, Moore CS, Prat A, Antel J, Arbour N. Sénécal V, et al. Among authors: newcombe j. Glia. 2016 Apr;64(4):553-69. doi: 10.1002/glia.22948. Epub 2015 Dec 9. Glia. 2016. PMID: 26649511

10

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide.

Colombo E, Di Dario M, Capitolo E, Chaabane L, Newcombe J, Martino G, Farina C. Colombo E, et al. Among authors: newcombe j. Ann Neurol. 2014 Sep;76(3):325-37. doi: 10.1002/ana.24217. Epub 2014 Jul 15. Ann Neurol. 2014. PMID: 25043204

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