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Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A.
Darby JF, Krysztofinska EM, Simpson PJ, Simon AC, Leznicki P, Sriskandarajah N, Bishop DS, Hale LR, Alfano C, Conte MR, Martínez-Lumbreras S, Thapaliya A, High S, Isaacson RL. Darby JF, et al. Among authors: thapaliya a. PLoS One. 2014 Nov 21;9(11):e113281. doi: 10.1371/journal.pone.0113281. eCollection 2014. PLoS One. 2014. PMID: 25415308 Free PMC article.
Structural and functional insights into the E3 ligase, RNF126.
Krysztofinska EM, Martínez-Lumbreras S, Thapaliya A, Evans NJ, High S, Isaacson RL. Krysztofinska EM, et al. Among authors: thapaliya a. Sci Rep. 2016 May 19;6:26433. doi: 10.1038/srep26433. Sci Rep. 2016. PMID: 27193484 Free PMC article.
A novel RNA polymerase-binding protein that interacts with a sigma-factor docking site.
Wang Erickson AF, Deighan P, Chen S, Barrasso K, Garcia CP, Martínez-Lumbreras S, Alfano C, Krysztofinska EM, Thapaliya A, Camp AH, Isaacson RL, Hochschild A, Losick R. Wang Erickson AF, et al. Among authors: thapaliya a. Mol Microbiol. 2017 Aug;105(4):652-662. doi: 10.1111/mmi.13724. Epub 2017 Jun 19. Mol Microbiol. 2017. PMID: 28598017 Free PMC article.
Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.
Martínez-Lumbreras S, Krysztofinska EM, Thapaliya A, Spilotros A, Matak-Vinkovic D, Salvadori E, Roboti P, Nyathi Y, Muench JH, Roessler MM, Svergun DI, High S, Isaacson RL. Martínez-Lumbreras S, et al. Among authors: thapaliya a. BMC Biol. 2018 Jul 11;16(1):76. doi: 10.1186/s12915-018-0542-3. BMC Biol. 2018. PMID: 29996828 Free PMC article.
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1.
Wilding B, Pasqua AE, E A Chessum N, Pierrat OA, Hahner T, Tomlin K, Shehu E, Burke R, Richards GM, Whitton B, Arwert EN, Thapaliya A, Salimraj R, van Montfort R, Skawinska A, Hayes A, Raynaud F, Chopra R, Jones K, Newton G, Cheeseman MD. Wilding B, et al. Among authors: thapaliya a. Bioorg Med Chem Lett. 2021 Jun 15;42:128050. doi: 10.1016/j.bmcl.2021.128050. Epub 2021 Apr 20. Bioorg Med Chem Lett. 2021. PMID: 33887439 Free PMC article.
Erratum: iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.
Bouguenina H, Nicolaou S, Bihan YL, Bowling EA, Calderon C, Caldwell JJ, Harrington B, Hayes A, McAndrew PC, Mitsopoulos C, Sialana FJ, Scarpino A, Stubbs M, Thapaliya A, Tyagi S, Wang HZ, Wood F, Burke R, Raynaud F, Choudhary J, van Montfort RLM, Sadok A, Westbrook TF, Collins I, Chopra R. Bouguenina H, et al. Among authors: thapaliya a. iScience. 2024 Apr 14;27(5):109727. doi: 10.1016/j.isci.2024.109727. eCollection 2024 May 17. iScience. 2024. PMID: 38646177 Free PMC article.
Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.
Liu M, Mirza A, McAndrew PC, Thapaliya A, Pierrat OA, Stubbs M, Hahner T, Chessum NEA, Innocenti P, Caldwell J, Cheeseman MD, Bellenie BR, van Montfort RLM, Newton GK, Burke R, Collins I, Hoelder S. Liu M, et al. Among authors: thapaliya a. J Med Chem. 2023 Aug 10;66(15):10617-10627. doi: 10.1021/acs.jmedchem.3c00758. Epub 2023 Jul 19. J Med Chem. 2023. PMID: 37467168 Free PMC article.
13 results