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AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro.
Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C. Szczesny B, et al. Nitric Oxide. 2014 Sep 15;41:120-30. doi: 10.1016/j.niox.2014.04.008. Epub 2014 Apr 19. Nitric Oxide. 2014. PMID: 24755204 Free PMC article.
Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
Coletta C, Módis K, Szczesny B, Brunyánszki A, Oláh G, Rios EC, Yanagi K, Ahmad A, Papapetropoulos A, Szabo C. Coletta C, et al. Among authors: szczesny b. Mol Med. 2015 Feb 18;21(1):1-14. doi: 10.2119/molmed.2015.00035. Mol Med. 2015. PMID: 25715337 Free PMC article.
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