Hwang TC - Search Results

1

CFTR potentiators: from bench to bedside.

Jih KY, Lin WY, Sohma Y, Hwang TC. Jih KY, et al. Among authors: hwang tc. Curr Opin Pharmacol. 2017 Jun;34:98-104. doi: 10.1016/j.coph.2017.09.015. Epub 2017 Nov 5. Curr Opin Pharmacol. 2017. PMID: 29073476 Free PMC article. Review.

2

CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).

Bompadre SG, Ai T, Cho JH, Wang X, Sohma Y, Li M, Hwang TC. Bompadre SG, et al. Among authors: hwang tc. J Gen Physiol. 2005 Apr;125(4):361-75. doi: 10.1085/jgp.200409227. Epub 2005 Mar 14. J Gen Physiol. 2005. PMID: 15767295 Free PMC article.

3

CFTR gating II: Effects of nucleotide binding on the stability of open states.

Bompadre SG, Cho JH, Wang X, Zou X, Sohma Y, Li M, Hwang TC. Bompadre SG, et al. Among authors: hwang tc. J Gen Physiol. 2005 Apr;125(4):377-94. doi: 10.1085/jgp.200409228. Epub 2005 Mar 14. J Gen Physiol. 2005. PMID: 15767296 Free PMC article.

4

High affinity ATP/ADP analogues as new tools for studying CFTR gating.

Zhou Z, Wang X, Li M, Sohma Y, Zou X, Hwang TC. Zhou Z, et al. Among authors: hwang tc. J Physiol. 2005 Dec 1;569(Pt 2):447-57. doi: 10.1113/jphysiol.2005.095083. Epub 2005 Oct 13. J Physiol. 2005. PMID: 16223764 Free PMC article.

5

G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects.

Bompadre SG, Sohma Y, Li M, Hwang TC. Bompadre SG, et al. Among authors: hwang tc. J Gen Physiol. 2007 Apr;129(4):285-98. doi: 10.1085/jgp.200609667. Epub 2007 Mar 12. J Gen Physiol. 2007. PMID: 17353351 Free PMC article.

6

State-dependent modulation of CFTR gating by pyrophosphate.

Tsai MF, Shimizu H, Sohma Y, Li M, Hwang TC. Tsai MF, et al. Among authors: hwang tc. J Gen Physiol. 2009 Apr;133(4):405-19. doi: 10.1085/jgp.200810186. J Gen Physiol. 2009. PMID: 19332621 Free PMC article.

7

A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR.

Shimizu H, Yu YC, Kono K, Kubota T, Yasui M, Li M, Hwang TC, Sohma Y. Shimizu H, et al. Among authors: hwang tc. J Physiol Sci. 2010 Sep;60(5):353-62. doi: 10.1007/s12576-010-0102-2. Epub 2010 Jul 14. J Physiol Sci. 2010. PMID: 20628841 Free PMC article.

8

Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels.

Tsai MF, Jih KY, Shimizu H, Li M, Hwang TC. Tsai MF, et al. Among authors: hwang tc. J Biol Chem. 2010 Nov 26;285(48):37663-71. doi: 10.1074/jbc.M110.172817. Epub 2010 Sep 22. J Biol Chem. 2010. PMID: 20861014 Free PMC article.

9

On the mechanism of CFTR inhibition by a thiazolidinone derivative.

Kopeikin Z, Sohma Y, Li M, Hwang TC. Kopeikin Z, et al. Among authors: hwang tc. J Gen Physiol. 2010 Dec;136(6):659-71. doi: 10.1085/jgp.201010518. Epub 2010 Nov 15. J Gen Physiol. 2010. PMID: 21078867 Free PMC article.

10

The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR.

Jih KY, Li M, Hwang TC, Bompadre SG. Jih KY, et al. Among authors: hwang tc. J Physiol. 2011 Jun 1;589(Pt 11):2719-31. doi: 10.1113/jphysiol.2010.202861. Epub 2011 Apr 11. J Physiol. 2011. PMID: 21486785 Free PMC article.

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