Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression.
Zheng M, Jiao L, Tang X, Xiang X, Wan X, Yan Y, Li X, Zhang G, Li Y, Jiang B, Cai H, Lin X.
Zheng M, et al. Among authors: tang x.
FASEB J. 2017 Aug;31(8):3349-3358. doi: 10.1096/fj.201601303R. Epub 2017 Apr 19.
FASEB J. 2017.
PMID: 28424350
Free PMC article.
Our findings highlight the impact of tau haploinsufficiency on the survival of mDANs and indicate that tau may participate in midbrain development in a dose-dependent way.-Zheng, M., Jiao, L., Tang, X., Xiang, X., Wan, X., Yan, Y., Li, X., Zhang …
Our findings highlight the impact of tau haploinsufficiency on the survival of mDANs and indicate that tau may participate in midbrain devel …