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First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
Pyka P, Haberek W, Więcek M, Szymanska E, Ali W, Cios A, Jastrzębska-Więsek M, Satała G, Podlewska S, Di Giacomo S, Di Sotto A, Garbo S, Karcz T, Lambona C, Marocco F, Latacz G, Sudoł-Tałaj S, Mordyl B, Głuch-Lutwin M, Siwek A, Czarnota-Łydka K, Gogola D, Olejarz-Maciej A, Wilczyńska-Zawal N, Honkisz-Orzechowska E, Starek M, Dąbrowska M, Kucwaj-Brysz K, Fioravanti R, Nasim MJ, Hittinger M, Partyka A, Wesołowska A, Battistelli C, Zwergel C, Handzlik J. Pyka P, et al. Among authors: siwek a. J Med Chem. 2024 Jan 25;67(2):1580-1610. doi: 10.1021/acs.jmedchem.3c02148. Epub 2024 Jan 8. J Med Chem. 2024. PMID: 38190615 Free PMC article.
Synthesis and biological evaluation of novel 3-(5-substituted-1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT.
Wróbel MZ, Chodkowski A, Dawidowski M, Siwek A, Stachowicz K, Szewczyk B, Nowak G, Satała G, Bojarski AJ, Turło J. Wróbel MZ, et al. Among authors: siwek a. Bioorg Chem. 2023 Dec;141:106903. doi: 10.1016/j.bioorg.2023.106903. Epub 2023 Oct 2. Bioorg Chem. 2023. PMID: 37827015 Free article.
Dual Molecules Targeting 5-HT6 and GABA-A Receptors as a New Approach to Combat Depression Associated with Neuroinflammation.
Marcinkowska M, Mordyl B, Siwek A, Głuch-Lutwin M, Karcz T, Gawalska A, Sapa M, Bucki A, Szafrańska K, Pomierny B, Pytka K, Kotańska M, Mika K, Kolaczkowski M. Marcinkowska M, et al. Among authors: siwek a. ACS Chem Neurosci. 2023 Apr 4;14(8):1474-89. doi: 10.1021/acschemneuro.3c00033. Online ahead of print. ACS Chem Neurosci. 2023. PMID: 37014731 Free PMC article.
190 results