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The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.
Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG. Herschhorn A, et al. Among authors: freire e. Nat Commun. 2017 Oct 19;8(1):1049. doi: 10.1038/s41467-017-01119-w. Nat Commun. 2017. PMID: 29051495 Free PMC article.
Thermodynamics of intersubunit interactions in cholera toxin upon binding to the oligosaccharide portion of its cell surface receptor, ganglioside GM1.
Schön A, Freire E. Schön A, et al. Among authors: freire e. Biochemistry. 1989 Jun 13;28(12):5019-24. doi: 10.1021/bi00438a017. Biochemistry. 1989. PMID: 2765522
Previously, we have shown that the association of cholera toxin to ganglioside GM1 enhances the cooperative interactions between subunits in the B-subunit pentamer [Goins, B., & Freire, E. (1988) Biochemistry 27, 2046-2052]. New experiments presented in this pap …
Previously, we have shown that the association of cholera toxin to ganglioside GM1 enhances the cooperative interactions between subunits in …
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.
Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed S, Steenbeke TD, Venturi M, Chaiken I, Fung M, Katinger H, Parren PW, Robinson J, Van Ryk D, Wang L, Burton DR, Freire E, Wyatt R, Sodroski J, Hendrickson WA, Arthos J. Kwong PD, et al. Among authors: freire e. Nature. 2002 Dec 12;420(6916):678-82. doi: 10.1038/nature01188. Nature. 2002. PMID: 12478295
Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions.
Biorn AC, Cocklin S, Madani N, Si Z, Ivanovic T, Samanen J, Van Ryk DI, Pantophlet R, Burton DR, Freire E, Sodroski J, Chaiken IM. Biorn AC, et al. Among authors: freire e. Biochemistry. 2004 Feb 24;43(7):1928-38. doi: 10.1021/bi035088i. Biochemistry. 2004. PMID: 14967033
Small-molecule inhibitors of HIV-1 entry block receptor-induced conformational changes in the viral envelope glycoproteins.
Si Z, Madani N, Cox JM, Chruma JJ, Klein JC, Schön A, Phan N, Wang L, Biorn AC, Cocklin S, Chaiken I, Freire E, Smith AB 3rd, Sodroski JG. Si Z, et al. Among authors: freire e. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5036-41. doi: 10.1073/pnas.0307953101. Epub 2004 Mar 29. Proc Natl Acad Sci U S A. 2004. PMID: 15051887 Free PMC article.
436 results