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Has molecular imaging delivered to drug development?
Murphy PS, Patel N, McCarthy TJ. Murphy PS, et al. Among authors: mccarthy tj. Philos Trans A Math Phys Eng Sci. 2017 Nov 28;375(2107):20170112. doi: 10.1098/rsta.2017.0112. Philos Trans A Math Phys Eng Sci. 2017. PMID: 29038381 Free PMC article. Review.
The role of clinical imaging in oncological drug development.
Murphy PS, McCarthy TJ, Dzik-Jurasz AS. Murphy PS, et al. Among authors: mccarthy tj. Br J Radiol. 2008 Sep;81(969):685-92. doi: 10.1259/bjr/16768437. Epub 2008 Jun 9. Br J Radiol. 2008. PMID: 18541632 Review.
The role of imaging in drug development.
McCarthy TJ. McCarthy TJ. Q J Nucl Med Mol Imaging. 2009 Aug;53(4):382-6. Q J Nucl Med Mol Imaging. 2009. PMID: 19834447 Free article.
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.
Zhang L, Villalobos A, Beck EM, Bocan T, Chappie TA, Chen L, Grimwood S, Heck SD, Helal CJ, Hou X, Humphrey JM, Lu J, Skaddan MB, McCarthy TJ, Verhoest PR, Wager TT, Zasadny K. Zhang L, et al. Among authors: mccarthy tj. J Med Chem. 2013 Jun 13;56(11):4568-79. doi: 10.1021/jm400312y. Epub 2013 May 28. J Med Chem. 2013. PMID: 23651455
Determination of receptor occupancy in the presence of mass dose: [11C]GSK189254 PET imaging of histamine H3 receptor occupancy by PF-03654746.
Gallezot JD, Planeta B, Nabulsi N, Palumbo D, Li X, Liu J, Rowinski C, Chidsey K, Labaree D, Ropchan J, Lin SF, Sawant-Basak A, McCarthy TJ, Schmidt AW, Huang Y, Carson RE. Gallezot JD, et al. Among authors: mccarthy tj. J Cereb Blood Flow Metab. 2017 Mar;37(3):1095-1107. doi: 10.1177/0271678X16650697. Epub 2016 Jul 20. J Cereb Blood Flow Metab. 2017. PMID: 27207170 Free PMC article.
Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy.
Maresca KP, Chen J, Mathur D, Giddabasappa A, Root A, Narula J, King L, Schaer D, Golas J, Kobylarz K, Rosfjord E, Keliher E, Chen L, Ram S, Pickering EH, Hardwick JS, Rejto PA, Hussein A, Ilovich O, Staton K, Wilson I, McCarthy TJ. Maresca KP, et al. Among authors: mccarthy tj. Mol Imaging Biol. 2021 Dec;23(6):941-951. doi: 10.1007/s11307-021-01621-0. Epub 2021 Jun 18. Mol Imaging Biol. 2021. PMID: 34143379 Free PMC article.
PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [18F]PF-06684511.
Arakawa R, Takano A, Stenkrona P, Stepanov V, Nag S, Jahan M, Grybäck P, Bolin M, Chen L, Zhang L, He P, Villalobos A, McCarthy TJ, Halldin C, Varrone A. Arakawa R, et al. Among authors: mccarthy tj. Eur J Nucl Med Mol Imaging. 2020 Sep;47(10):2429-2439. doi: 10.1007/s00259-020-04739-5. Epub 2020 Mar 6. Eur J Nucl Med Mol Imaging. 2020. PMID: 32140803 Free PMC article.
199 results