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Anticancer effect of acid ceramidase inhibitor ceranib-2 in human breast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, downregulation of ERα.
Anticancer Drugs. 2018 Jan;29(1):50-60. doi: 10.1097/CAD.0000000000000566.
Anticancer Drugs. 2018.
PMID: 29023248
Acid ceramidase, a double-edged sword in cancer aggression: A minireview.
Vethakanraj HS, Chandrasekaran N, Sekar AK.
Vethakanraj HS, et al.
Curr Cancer Drug Targets. 2020 Dec 23. doi: 10.2174/1568009620666201223154621. Online ahead of print.
Curr Cancer Drug Targets. 2020.
PMID: 33357194
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Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines.
Vethakanraj HS, Babu TA, Sudarsanan GB, Duraisamy PK, Ashok Kumar S.
Vethakanraj HS, et al.
Biochem Biophys Res Commun. 2015 Aug 28;464(3):833-9. doi: 10.1016/j.bbrc.2015.07.047. Epub 2015 Jul 15.
Biochem Biophys Res Commun. 2015.
PMID: 26188095
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