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Host-targeted nitazoxanide has a high barrier to resistance but does not reduce the emergence or proliferation of oseltamivir-resistant influenza viruses in vitro or in vivo when used in combination with oseltamivir.
Tilmanis D, Koszalka P, Barr IG, Rossignol JF, Mifsud E, Hurt AC. Tilmanis D, et al. Among authors: rossignol jf. Antiviral Res. 2020 Aug;180:104851. doi: 10.1016/j.antiviral.2020.104851. Epub 2020 Jun 13. Antiviral Res. 2020. PMID: 32544408
Viral burden, inflammatory milieu and CD8+ T-cell responses to influenza virus in a second-generation thiazolide (RM-5061) and oseltamivir combination therapy study.
Nüssing S, Mifsud E, Hensen L, Koutsakos M, Wang Z, Kedzierski L, Mercuri F, Rossignol JF, Hurt AC, Kedzierska K. Nüssing S, et al. Among authors: rossignol jf. Influenza Other Respir Viruses. 2020 Nov;14(6):678-687. doi: 10.1111/irv.12776. Epub 2020 Jun 25. Influenza Other Respir Viruses. 2020. PMID: 32588557 Free PMC article.
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