Okochi M - Search Results

1

Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.

Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M. Tagami S, et al. Among authors: okochi m. Cell Rep. 2017 Oct 3;21(1):259-273. doi: 10.1016/j.celrep.2017.09.032. Cell Rep. 2017. PMID: 28978478 Free article.

2

Cell-cycle-dependent abnormal calcium response in fibroblasts from patients with familial Alzheimer's disease.

Tatebayashi Y, Takeda M, Kashiwagi Y, Okochi M, Kurumadani T, Sekiyama A, Kanayama G, Hariguchi S, Nishimura T. Tatebayashi Y, et al. Among authors: okochi m. Dementia. 1995 Jan-Feb;6(1):9-16. doi: 10.1159/000106916. Dementia. 1995. PMID: 7728221

3

FAD-linked presenilin-1 mutants impede translation regulation under ER stress.

Yasuda Y, Kudo T, Katayama T, Imaizumi K, Yatera M, Okochi M, Yamamori H, Matsumoto N, Kida T, Fukumori A, Okumura M, Tohyama M, Takeda M. Yasuda Y, et al. Among authors: okochi m. Biochem Biophys Res Commun. 2002 Aug 16;296(2):313-8. doi: 10.1016/s0006-291x(02)00859-8. Biochem Biophys Res Commun. 2002. PMID: 12163019

4

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C. Lammich S, et al. Among authors: okochi m. J Biol Chem. 2002 Nov 22;277(47):44754-9. doi: 10.1074/jbc.M206872200. Epub 2002 Sep 9. J Biol Chem. 2002. PMID: 12223485 Free article.

5

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Okochi M, et al. EMBO J. 2002 Oct 15;21(20):5408-16. doi: 10.1093/emboj/cdf541. EMBO J. 2002. PMID: 12374741 Free PMC article.

6

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.

Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C. Fluhrer R, et al. Among authors: okochi m. J Biol Chem. 2003 Feb 21;278(8):5531-8. doi: 10.1074/jbc.M211485200. Epub 2002 Dec 5. J Biol Chem. 2003. PMID: 12471021 Free article.

7

The unfolded protein response is involved in the pathology of Alzheimer's disease.

Kudo T, Katayama T, Imaizumi K, Yasuda Y, Yatera M, Okochi M, Tohyama M, Takeda M. Kudo T, et al. Among authors: okochi m. Ann N Y Acad Sci. 2002 Nov;977:349-55. doi: 10.1111/j.1749-6632.2002.tb04837.x. Ann N Y Acad Sci. 2002. PMID: 12480772

8

[The amyloid beta protein generating mechanism simultaneously generates several other peptides in Alzheimer disease--discovery of new notch-beta peptide and the possibility of its use as a marker for the diagnosis of Alzheimer disease].

Okochi M, Takeda M. Okochi M, et al. Seishin Shinkeigaku Zasshi. 2003;105(1):87-96. Seishin Shinkeigaku Zasshi. 2003. PMID: 12701215 Review. Japanese. No abstract available.

9

[Familial Alzheimer's disease by beta-amyloid protein precursor (beta APP) mutations].

Okochi M, Takeda M. Okochi M, et al. Nihon Rinsho. 2004 Jan;62 Suppl:86-9. Nihon Rinsho. 2004. PMID: 15011326 Review. Japanese. No abstract available.

10

[Biological markers for diagnosis of Alzheimer's disease].

Takeda M, Tanaka T, Kudo T, Okochi M, Kamino A, Tagami S. Takeda M, et al. Among authors: okochi m. Seishin Shinkeigaku Zasshi. 2004;106(12):1610-4. Seishin Shinkeigaku Zasshi. 2004. PMID: 15770965 Review. Japanese. No abstract available.

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