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Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity.
Dos Santos Fernandes GF, de Souza PC, Moreno-Viguri E, Santivañez-Veliz M, Paucar R, Pérez-Silanes S, Chegaev K, Guglielmo S, Lazzarato L, Fruttero R, Man Chin C, da Silva PB, Chorilli M, Solcia MC, Ribeiro CM, Silva CSP, Marino LB, Bosquesi PL, Hunt DM, de Carvalho LPS, de Souza Costa CA, Cho SH, Wang Y, Franzblau SG, Pavan FR, Dos Santos JL. Dos Santos Fernandes GF, et al. Among authors: hunt dm. J Med Chem. 2017 Oct 26;60(20):8647-8660. doi: 10.1021/acs.jmedchem.7b01332. Epub 2017 Oct 16. J Med Chem. 2017. PMID: 28968083 Free PMC article.
Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism.
Serafini A, Tan L, Horswell S, Howell S, Greenwood DJ, Hunt DM, Phan MD, Schembri M, Monteleone M, Montague CR, Britton W, Garza-Garcia A, Snijders AP, VanderVen B, Gutierrez MG, West NP, de Carvalho LPS. Serafini A, et al. Among authors: hunt dm. Mol Microbiol. 2019 Oct;112(4):1284-1307. doi: 10.1111/mmi.14362. Epub 2019 Aug 23. Mol Microbiol. 2019. PMID: 31389636 Free PMC article.
A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor.
Rickman L, Scott C, Hunt DM, Hutchinson T, Menéndez MC, Whalan R, Hinds J, Colston MJ, Green J, Buxton RS. Rickman L, et al. Among authors: hunt dm. Mol Microbiol. 2005 Jun;56(5):1274-86. doi: 10.1111/j.1365-2958.2005.04609.x. Mol Microbiol. 2005. PMID: 15882420 Free PMC article.
346 results