Skamnaki VT - Search Results

1

Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.

Bokor É, Kyriakis E, Solovou TGA, Koppány C, Kantsadi AL, Szabó KE, Szakács A, Stravodimos GA, Docsa T, Skamnaki VT, Zographos SE, Gergely P, Leonidas DD, Somsák L. Bokor É, et al. Among authors: skamnaki vt. J Med Chem. 2017 Nov 22;60(22):9251-9262. doi: 10.1021/acs.jmedchem.7b01056. Epub 2017 Oct 3. J Med Chem. 2017. PMID: 28925695

2

The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor.

Zographos SE, Oikonomakos NG, Tsitsanou KE, Leonidas DD, Chrysina ED, Skamnaki VT, Bischoff H, Goldmann S, Watson KA, Johnson LN. Zographos SE, et al. Among authors: skamnaki vt. Structure. 1997 Nov 15;5(11):1413-25. doi: 10.1016/s0969-2126(97)00292-x. Structure. 1997. PMID: 9384557 Free article.

3

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.

Tsitsanou KE, Oikonomakos NG, Zographos SE, Skamnaki VT, Gregoriou M, Watson KA, Johnson LN, Fleet GW. Tsitsanou KE, et al. Among authors: skamnaki vt. Protein Sci. 1999 Apr;8(4):741-9. doi: 10.1110/ps.8.4.741. Protein Sci. 1999. PMID: 10211820 Free PMC article.

4

Allosteric inhibition of glycogen phosphorylase a by the potential antidiabetic drug 3-isopropyl 4-(2-chlorophenyl)-1,4-dihydro-1-ethyl-2-methyl-pyridine-3,5,6-tricarbo xylate.

Oikonomakos NG, Tsitsanou KE, Zographos SE, Skamnaki VT, Goldmann S, Bischoff H. Oikonomakos NG, et al. Among authors: skamnaki vt. Protein Sci. 1999 Oct;8(10):1930-45. doi: 10.1110/ps.8.10.1930. Protein Sci. 1999. PMID: 10548038 Free PMC article.

5

A new allosteric site in glycogen phosphorylase b as a target for drug interactions.

Oikonomakos NG, Skamnaki VT, Tsitsanou KE, Gavalas NG, Johnson LN. Oikonomakos NG, et al. Among authors: skamnaki vt. Structure. 2000 Jun 15;8(6):575-84. doi: 10.1016/s0969-2126(00)00144-1. Structure. 2000. PMID: 10873856 Free article.

6

Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.

Oikonomakos NG, Schnier JB, Zographos SE, Skamnaki VT, Tsitsanou KE, Johnson LN. Oikonomakos NG, et al. Among authors: skamnaki vt. J Biol Chem. 2000 Nov 3;275(44):34566-73. doi: 10.1074/jbc.M004485200. J Biol Chem. 2000. PMID: 10924512 Free article.

7

Kinetic characterization of the double mutant R148A/E182S of glycogen phosphorylase kinase catalytic subunit: the role of the activation loop.

Skamnaki VT, Oikonomakos NG. Skamnaki VT, et al. J Protein Chem. 2000 Aug;19(6):499-505. doi: 10.1023/a:1026553532289. J Protein Chem. 2000. PMID: 11195974

8

Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug.

Tsitsanou KE, Skamnaki VT, Oikonomakos NG. Tsitsanou KE, et al. Among authors: skamnaki vt. Arch Biochem Biophys. 2000 Dec 15;384(2):245-54. doi: 10.1006/abbi.2000.2121. Arch Biochem Biophys. 2000. PMID: 11368311

9

The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment.

Kantsadi AL, Manta S, Psarra AM, Dimopoulou A, Kiritsis C, Parmenopoulou V, Skamnaki VT, Zoumpoulakis P, Zographos SE, Leonidas DD, Komiotis D. Kantsadi AL, et al. Among authors: skamnaki vt. Eur J Med Chem. 2012 Aug;54:740-9. doi: 10.1016/j.ejmech.2012.06.029. Epub 2012 Jun 22. Eur J Med Chem. 2012. PMID: 22770609

10

Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.

Parmenopoulou V, Chatzileontiadou DS, Manta S, Bougiatioti S, Maragozidis P, Gkaragkouni DN, Kaffesaki E, Kantsadi AL, Skamnaki VT, Zographos SE, Zounpoulakis P, Balatsos NA, Komiotis D, Leonidas DD. Parmenopoulou V, et al. Among authors: skamnaki vt. Bioorg Med Chem. 2012 Dec 15;20(24):7184-93. doi: 10.1016/j.bmc.2012.09.067. Epub 2012 Oct 16. Bioorg Med Chem. 2012. PMID: 23122937

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