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Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4.
Hanley CJ, Mellone M, Ford K, Thirdborough SM, Mellows T, Frampton SJ, Smith DM, Harden E, Szyndralewiez C, Bullock M, Noble F, Moutasim KA, King EV, Vijayanand P, Mirnezami AH, Underwood TJ, Ottensmeier CH, Thomas GJ. Hanley CJ, et al. Among authors: thirdborough sm. J Natl Cancer Inst. 2018 Jan 1;110(1):109-20. doi: 10.1093/jnci/djx121. J Natl Cancer Inst. 2018. PMID: 28922779 Free PMC article.
A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers.
Hanley CJ, Noble F, Ward M, Bullock M, Drifka C, Mellone M, Manousopoulou A, Johnston HE, Hayden A, Thirdborough S, Liu Y, Smith DM, Mellows T, Kao WJ, Garbis SD, Mirnezami A, Underwood TJ, Eliceiri KW, Thomas GJ. Hanley CJ, et al. Oncotarget. 2016 Feb 2;7(5):6159-74. doi: 10.18632/oncotarget.6740. Oncotarget. 2016. PMID: 26716418 Free PMC article.
Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis.
Mellone M, Hanley CJ, Thirdborough S, Mellows T, Garcia E, Woo J, Tod J, Frampton S, Jenei V, Moutasim KA, Kabir TD, Brennan PA, Venturi G, Ford K, Herranz N, Lim KP, Clarke J, Lambert DW, Prime SS, Underwood TJ, Vijayanand P, Eliceiri KW, Woelk C, King EV, Gil J, Ottensmeier CH, Thomas GJ. Mellone M, et al. Aging (Albany NY). 2016 Dec 15;9(1):114-132. doi: 10.18632/aging.101127. Aging (Albany NY). 2016. PMID: 27992856 Free PMC article.
Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression.
Bhome R, Goh RW, Bullock MD, Pillar N, Thirdborough SM, Mellone M, Mirnezami R, Galea D, Veselkov K, Gu Q, Underwood TJ, Primrose JN, De Wever O, Shomron N, Sayan AE, Mirnezami AH. Bhome R, et al. Among authors: thirdborough sm. Aging (Albany NY). 2017 Dec 28;9(12):2666-2694. doi: 10.18632/aging.101355. Aging (Albany NY). 2017. PMID: 29283887 Free PMC article.
Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR-200 levels in extracellular vesicles.
Bhome R, Emaduddin M, James V, House LM, Thirdborough SM, Mellone M, Tulkens J, Primrose JN, Thomas GJ, De Wever O, Mirnezami AH, Sayan AE. Bhome R, et al. Among authors: thirdborough sm. J Extracell Vesicles. 2022 May;11(5):e12226. doi: 10.1002/jev2.12226. J Extracell Vesicles. 2022. PMID: 35595718 Free PMC article.
Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer.
Ward MJ, Thirdborough SM, Mellows T, Riley C, Harris S, Suchak K, Webb A, Hampton C, Patel NN, Randall CJ, Cox HJ, Jogai S, Primrose J, Piper K, Ottensmeier CH, King EV, Thomas GJ. Ward MJ, et al. Among authors: thirdborough sm. Br J Cancer. 2014 Jan 21;110(2):489-500. doi: 10.1038/bjc.2013.639. Epub 2013 Oct 29. Br J Cancer. 2014. PMID: 24169344 Free PMC article.
Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx.
Chakravarthy A, Henderson S, Thirdborough SM, Ottensmeier CH, Su X, Lechner M, Feber A, Thomas GJ, Fenton TR. Chakravarthy A, et al. Among authors: thirdborough sm. J Clin Oncol. 2016 Dec;34(34):4132-4141. doi: 10.1200/JCO.2016.68.2955. Epub 2016 Oct 31. J Clin Oncol. 2016. PMID: 27863190 Free PMC article.
41 results