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Shaping Substrate Selectivity in a Broad-Spectrum Metallo-β-Lactamase.
González LJ, Stival C, Puzzolo JL, Moreno DM, Vila AJ. González LJ, et al. Among authors: moreno dm. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02079-17. doi: 10.1128/AAC.02079-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29358299 Free PMC article.
2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode.
Hinchliffe P, Moreno DM, Rossi MA, Mojica MF, Martinez V, Villamil V, Spellberg B, Drusano GL, Banchio C, Mahler G, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: moreno dm. ACS Infect Dis. 2021 Sep 10;7(9):2697-2706. doi: 10.1021/acsinfecdis.1c00194. Epub 2021 Aug 6. ACS Infect Dis. 2021. PMID: 34355567 Free PMC article.
Longitudinal Evolution of the Pseudomonas-Derived Cephalosporinase (PDC) Structure and Activity in a Cystic Fibrosis Patient Treated with β-Lactams.
Colque CA, Albarracín Orio AG, Tomatis PE, Dotta G, Moreno DM, Hedemann LG, Hickman RA, Sommer LM, Feliziani S, Moyano AJ, Bonomo RA, K Johansen H, Molin S, Vila AJ, Smania AM. Colque CA, et al. Among authors: moreno dm. mBio. 2022 Oct 26;13(5):e0166322. doi: 10.1128/mbio.01663-22. Epub 2022 Sep 8. mBio. 2022. PMID: 36073814 Free PMC article.
Correction: 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases.
Rossi MA, Martinez V, Hinchliffe P, Mojica MF, Castillo V, Moreno DM, Smith R, Spellberg B, Drusano GL, Banchio C, Bonomo RA, Spencer J, Vila AJ, Mahler G. Rossi MA, et al. Among authors: moreno dm. Chem Sci. 2023 Aug 15;14(34):9226. doi: 10.1039/d3sc90150e. eCollection 2023 Aug 30. Chem Sci. 2023. PMID: 37655038 Free PMC article.
Structural basis of metallo-β-lactamase resistance to taniborbactam.
Drusin SI, Le Terrier C, Poirel L, Bonomo RA, Vila AJ, Moreno DM. Drusin SI, et al. Among authors: moreno dm. Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0116823. doi: 10.1128/aac.01168-23. Epub 2023 Dec 8. Antimicrob Agents Chemother. 2024. PMID: 38063400 Free article.
49 results