Berkowitz DB - Search Results

1

Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.

McCune CD, Beio ML, Sturdivant JM, de la Salud-Bea R, Darnell BM, Berkowitz DB. McCune CD, et al. Among authors: berkowitz db. J Am Chem Soc. 2017 Oct 11;139(40):14077-14089. doi: 10.1021/jacs.7b04690. Epub 2017 Sep 28. J Am Chem Soc. 2017. PMID: 28906111 Free PMC article.

2

Engineering acyclic stereocontrol in the alkylation of vinylglycine-derived dianions: asymmetric synthesis of higher alpha-vinyl amino acids.

Berkowitz DB, McFadden JM, Sloss MK. Berkowitz DB, et al. J Org Chem. 2000 May 19;65(10):2907-18. doi: 10.1021/jo9918091. J Org Chem. 2000. PMID: 10814177 Free PMC article.

3

Synthesis of quaternary amino acids bearing a (2'Z)-fluorovinyl alpha-branch: potential PLP enzyme inactivators.

Berkowitz DB, de la Salud-Bea R, Jahng WJ. Berkowitz DB, et al. Org Lett. 2004 May 27;6(11):1821-4. doi: 10.1021/ol049422u. Org Lett. 2004. PMID: 15151423 Free PMC article.

4

Double-cuvette ISES: in situ estimation of enantioselectivity and relative rate for catalyst screening.

Dey S, Karukurichi KR, Shen W, Berkowitz DB. Dey S, et al. Among authors: berkowitz db. J Am Chem Soc. 2005 Jun 22;127(24):8610-1. doi: 10.1021/ja052010b. J Am Chem Soc. 2005. PMID: 15954763

5

A formal [3,3]-sigmatropic rearrangement route to quaternary alpha-vinyl amino acids: use of allylic N-PMP trifluoroacetimidates.

Berkowitz DB, Wu B, Li H. Berkowitz DB, et al. Org Lett. 2006 Mar 2;8(5):971-4. doi: 10.1021/ol060019s. Org Lett. 2006. PMID: 16494487 Free PMC article.

6

Examination of the new alpha-(2'Z-fluoro)vinyl trigger with lysine decarboxylase: the absolute stereochemistry dictates the reaction course.

Karukurichi KR, de la Salud-Bea R, Jahng WJ, Berkowitz DB. Karukurichi KR, et al. Among authors: berkowitz db. J Am Chem Soc. 2007 Jan 17;129(2):258-9. doi: 10.1021/ja067240k. J Am Chem Soc. 2007. PMID: 17212389 Free PMC article.

7

Use of Fluorinated Functionality in Enzyme Inhibitor Development: Mechanistic and Analytical Advantages.

Berkowitz DB, Karukurichi KR, de la Salud-Bea R, Nelson DL, McCune CD. Berkowitz DB, et al. J Fluor Chem. 2008 Sep;129(9):731-742. doi: 10.1016/j.jfluchem.2008.05.016. J Fluor Chem. 2008. PMID: 19727327 Free PMC article.

8

Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysis-dynamic reductive kinetic resolution entry into (S)-profens.

Friest JA, Maezato Y, Broussy S, Blum P, Berkowitz DB. Friest JA, et al. Among authors: berkowitz db. J Am Chem Soc. 2010 May 5;132(17):5930-1. doi: 10.1021/ja910778p. J Am Chem Soc. 2010. PMID: 20377222 Free PMC article.

9

Synthesis of α-Vinyl Amino Acids.

Berkowitz DB, McFadden JM, Smith MK, Pedersen ML. Berkowitz DB, et al. Methods Mol Med. 1999;23:467-88. doi: 10.1385/0-89603-517-4:467. Methods Mol Med. 1999. PMID: 21380914

10

Combining a Clostridial enzyme exhibiting unusual active site plasticity with a remarkably facile sigmatropic rearrangement: rapid, stereocontrolled entry into densely functionalized fluorinated phosphonates for chemical biology.

Panigrahi K, Applegate GA, Malik G, Berkowitz DB. Panigrahi K, et al. Among authors: berkowitz db. J Am Chem Soc. 2015 Mar 18;137(10):3600-9. doi: 10.1021/jacs.5b00022. Epub 2015 Mar 5. J Am Chem Soc. 2015. PMID: 25719907 Free PMC article.

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