Rauh D - Search Results

1

Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK.

Bührmann M, Wiedemann BM, Müller MP, Hardick J, Ecke M, Rauh D. Bührmann M, et al. Among authors: rauh d. PLoS One. 2017 Sep 11;12(9):e0184627. doi: 10.1371/journal.pone.0184627. eCollection 2017. PLoS One. 2017. PMID: 28892510 Free PMC article.

2

Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.

Simard JR, Getlik M, Grütter C, Pawar V, Wulfert S, Rabiller M, Rauh D. Simard JR, et al. Among authors: rauh d. J Am Chem Soc. 2009 Sep 23;131(37):13286-96. doi: 10.1021/ja902010p. J Am Chem Soc. 2009. PMID: 19572644

3

Displacement assay for the detection of stabilizers of inactive kinase conformations.

Klüter S, Grütter C, Naqvi T, Rabiller M, Simard JR, Pawar V, Getlik M, Rauh D. Klüter S, et al. Among authors: rauh d. J Med Chem. 2010 Jan 14;53(1):357-67. doi: 10.1021/jm901297e. J Med Chem. 2010. PMID: 19928858

4

High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha.

Simard JR, Grütter C, Pawar V, Aust B, Wolf A, Rabiller M, Wulfert S, Robubi A, Klüter S, Ottmann C, Rauh D. Simard JR, et al. Among authors: rauh d. J Am Chem Soc. 2009 Dec 30;131(51):18478-88. doi: 10.1021/ja907795q. J Am Chem Soc. 2009. PMID: 19950957

5

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

Getlik M, Grütter C, Simard JR, Nguyen HD, Robubi A, Aust B, van Otterlo WA, Rauh D. Getlik M, et al. Among authors: rauh d. Eur J Med Chem. 2012 Feb;48:1-15. doi: 10.1016/j.ejmech.2011.11.019. Epub 2011 Nov 18. Eur J Med Chem. 2012. PMID: 22154891

6

Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38α kinase.

Getlik M, Simard JR, Termathe M, Grütter C, Rabiller M, van Otterlo WA, Rauh D. Getlik M, et al. Among authors: rauh d. PLoS One. 2012;7(7):e39713. doi: 10.1371/journal.pone.0039713. Epub 2012 Jul 2. PLoS One. 2012. PMID: 22768308 Free PMC article.

7

FLiK: a direct-binding assay for the identification and kinetic characterization of stabilizers of inactive kinase conformations.

Simard JR, Rauh D. Simard JR, et al. Among authors: rauh d. Methods Enzymol. 2014;548:147-71. doi: 10.1016/B978-0-12-397918-6.00006-9. Methods Enzymol. 2014. PMID: 25399645 Review.

8

Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.

Engel J, Richters A, Getlik M, Tomassi S, Keul M, Termathe M, Lategahn J, Becker C, Mayer-Wrangowski S, Grütter C, Uhlenbrock N, Krüll J, Schaumann N, Eppmann S, Kibies P, Hoffgaard F, Heil J, Menninger S, Ortiz-Cuaran S, Heuckmann JM, Tinnefeld V, Zahedi RP, Sos ML, Schultz-Fademrecht C, Thomas RK, Kast SM, Rauh D. Engel J, et al. Among authors: rauh d. J Med Chem. 2015 Sep 10;58(17):6844-63. doi: 10.1021/acs.jmedchem.5b01082. Epub 2015 Aug 31. J Med Chem. 2015. PMID: 26275028

9

Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.

Halekotte J, Witt L, Ianes C, Krüger M, Bührmann M, Rauh D, Pichlo C, Brunstein E, Luxenburger A, Baumann U, Knippschild U, Bischof J, Peifer C. Halekotte J, et al. Among authors: rauh d. Molecules. 2017 Mar 24;22(4):522. doi: 10.3390/molecules22040522. Molecules. 2017. PMID: 28338621 Free PMC article.

10

Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.

Wentsch HK, Walter NM, Bührmann M, Mayer-Wrangowski S, Rauh D, Zaman GJR, Willemsen-Seegers N, Buijsman RC, Henning M, Dauch D, Zender L, Laufer S. Wentsch HK, et al. Among authors: rauh d. Angew Chem Int Ed Engl. 2017 May 2;56(19):5363-5367. doi: 10.1002/anie.201701185. Epub 2017 Apr 11. Angew Chem Int Ed Engl. 2017. PMID: 28397331

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