Paini A - Search Results

1

Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications.

Paini A, Leonard JA, Kliment T, Tan YM, Worth A. Paini A, et al. Regul Toxicol Pharmacol. 2017 Nov;90:104-115. doi: 10.1016/j.yrtph.2017.08.019. Epub 2017 Sep 1. Regul Toxicol Pharmacol. 2017. PMID: 28866268 Free PMC article.

2

In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine.

Gajewska M, Paini A, Sala Benito JV, Burton J, Worth A, Urani C, Briesen H, Schramm KW. Gajewska M, et al. Among authors: paini a. Food Chem Toxicol. 2015 Jan;75:39-49. doi: 10.1016/j.fct.2014.10.017. Epub 2014 Nov 4. Food Chem Toxicol. 2015. PMID: 25455898 Free article.

3

Multiscale modelling approaches for assessing cosmetic ingredients safety.

Bois FY, Ochoa JGD, Gajewska M, Kovarich S, Mauch K, Paini A, Péry A, Benito JVS, Teng S, Worth A. Bois FY, et al. Among authors: paini a. Toxicology. 2017 Dec 1;392:130-139. doi: 10.1016/j.tox.2016.05.026. Epub 2016 Jun 4. Toxicology. 2017. PMID: 27267299 Free article.

4

Theoretical and mathematical foundation of the Virtual Cell Based Assay - A review.

Comenges JMZ, Joossens E, Benito JVS, Worth A, Paini A. Comenges JMZ, et al. Among authors: paini a. Toxicol In Vitro. 2017 Dec;45(Pt 2):209-221. doi: 10.1016/j.tiv.2016.07.013. Epub 2016 Jul 26. Toxicol In Vitro. 2017. PMID: 27470131 Free article. Review.

5

Practical use of the Virtual Cell Based Assay: Simulation of repeated exposure experiments in liver cell lines.

Paini A, Mennecozzi M, Horvat T, Gerloff K, Palosaari T, Sala Benito JV, Worth A. Paini A, et al. Toxicol In Vitro. 2017 Dec;45(Pt 2):233-240. doi: 10.1016/j.tiv.2016.10.007. Epub 2016 Oct 14. Toxicol In Vitro. 2017. PMID: 27746372 Free article.

6

The virtual cell based assay: Current status and future perspectives.

Graepel R, Lamon L, Asturiol D, Berggren E, Joossens E, Paini A, Prieto P, Whelan M, Worth A. Graepel R, et al. Among authors: paini a. Toxicol In Vitro. 2017 Dec;45(Pt 2):258-267. doi: 10.1016/j.tiv.2017.01.009. Epub 2017 Jan 18. Toxicol In Vitro. 2017. PMID: 28108195 Free PMC article.

7

The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data - A case study with caffeine.

Bessems JGM, Paini A, Gajewska M, Worth A. Bessems JGM, et al. Among authors: paini a. Toxicology. 2017 Dec 1;392:119-129. doi: 10.1016/j.tox.2017.03.012. Epub 2017 Mar 10. Toxicology. 2017. PMID: 28288858 Free PMC article.

8

Automated workflows for modelling chemical fate, kinetics and toxicity.

Sala Benito JV, Paini A, Richarz AN, Meinl T, Berthold MR, Cronin MTD, Worth AP. Sala Benito JV, et al. Among authors: paini a. Toxicol In Vitro. 2017 Dec;45(Pt 2):249-257. doi: 10.1016/j.tiv.2017.03.004. Epub 2017 Mar 18. Toxicol In Vitro. 2017. PMID: 28323105 Free PMC article.

9

From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling.

Paini A, Sala Benito JV, Bessems J, Worth AP. Paini A, et al. Toxicol In Vitro. 2017 Dec;45(Pt 2):241-248. doi: 10.1016/j.tiv.2017.06.015. Epub 2017 Jun 27. Toxicol In Vitro. 2017. PMID: 28663056 Free PMC article.

10

Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes.

Worth AP, Louisse J, Macko P, Sala Benito JV, Paini A. Worth AP, et al. Among authors: paini a. Toxicol In Vitro. 2017 Dec;45(Pt 2):222-232. doi: 10.1016/j.tiv.2017.09.009. Epub 2017 Sep 11. Toxicol In Vitro. 2017. PMID: 28911986 Free PMC article.

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